%0 Journal Article %1 Glinianaia2002 %A Glinianaia, S. V. %A Pharoah, P. O D %A Wright, C. %A Rankin, J. M. %A Group, Northern Region Perinatal Mortality Survey Steering %D 2002 %J Arch Dis Child Fetal Neonatal Ed %K Brain Diseases; Cause of Death; Cerebral Palsy; Diseases in Twins; England; Female; Fetal Fetofetal Transfusion; Follow-Up Studies; Gestational Age; Humans; Infant Mortality; Infant, Newborn; Male; Pregnancy; Prevalence; Risk Factors; Sex Factors %N 1 %P F9--15 %T Fetal or infant death in twin pregnancy: neurodevelopmental consequence for the survivor. %V 86 %X AIM: To determine the neurodevelopmental morbidity in the surviving twin after fetal or infant death of the co-twin. METHODS: Twin pregnancies with an antepartum or infant death delivered between 1981 and 1992 were identified from the Northern Perinatal Mortality Survey. Information on the neurodevelopmental morbidity of infant survivors of a deceased co-twin was obtained by a questionnaire sent to the community paediatrician or general practitioner. RESULTS: A total of 111 children who survived infancy after the fetal death of the co-twin (group 1) and 142 from liveborn twin pairs in which one twin died in infancy (group 2) were traced. Responses were received from 97 (87\%) and 130 (92\%) respectively. In group 1, the cerebral palsy prevalence was 93 (95\% confidence interval (CI) 43 to 169) per 1000 infant survivors; it was more common in like-sex pairs (8/70) with a prevalence of 114 (95\% CI 51 to 213) compared with 45 (95\% CI 1 to 228) per 1000 infant survivors in unlike-sex pairs (1/22). The overall prevalence of neurodevelopmental morbidity (including developmental delay) was 175 (95\% CI 106 to 266) per 1000. In group 2, the cerebral palsy prevalence was 154 (95\% CI 84 to 223) per 1000 infant survivors in like-sex (16/104) and 77 (95\% CI 9 to 251) in unlike-sex (2/26) survivors; the overall prevalence of neurodevelopmental morbidity was 246 (95\% CI 172 to 320) per 1000. CONCLUSIONS: The risk of cerebral palsy is increased in the surviving twin after a fetal or infant co-twin death compared with the general twin population. Like-sex twins are at greater risk than unlike-sex. The probable cause, in addition to the consequences of prematurity, is twin-twin transfusion problems associated with monochorionicity.

@article{Glinianaia2002, abstract = {AIM: To determine the neurodevelopmental morbidity in the surviving twin after fetal or infant death of the co-twin. METHODS: Twin pregnancies with an antepartum or infant death delivered between 1981 and 1992 were identified from the Northern Perinatal Mortality Survey. Information on the neurodevelopmental morbidity of infant survivors of a deceased co-twin was obtained by a questionnaire sent to the community paediatrician or general practitioner. RESULTS: A total of 111 children who survived infancy after the fetal death of the co-twin (group 1) and 142 from liveborn twin pairs in which one twin died in infancy (group 2) were traced. Responses were received from 97 (87\%) and 130 (92\%) respectively. In group 1, the cerebral palsy prevalence was 93 (95\% confidence interval (CI) 43 to 169) per 1000 infant survivors; it was more common in like-sex pairs (8/70) with a prevalence of 114 (95\% CI 51 to 213) compared with 45 (95\% CI 1 to 228) per 1000 infant survivors in unlike-sex pairs (1/22). The overall prevalence of neurodevelopmental morbidity (including developmental delay) was 175 (95\% CI 106 to 266) per 1000. In group 2, the cerebral palsy prevalence was 154 (95\% CI 84 to 223) per 1000 infant survivors in like-sex (16/104) and 77 (95\% CI 9 to 251) in unlike-sex (2/26) survivors; the overall prevalence of neurodevelopmental morbidity was 246 (95\% CI 172 to 320) per 1000. CONCLUSIONS: The risk of cerebral palsy is increased in the surviving twin after a fetal or infant co-twin death compared with the general twin population. Like-sex twins are at greater risk than unlike-sex. The probable cause, in addition to the consequences of prematurity, is twin-twin transfusion problems associated with monochorionicity.}, added-at = {2014-07-19T19:33:20.000+0200}, author = {Glinianaia, S. V. and Pharoah, P. O D and Wright, C. and Rankin, J. M. and Group, Northern Region Perinatal Mortality Survey Steering}, biburl = {https://www.bibsonomy.org/bibtex/2f670f43faaf59096428c41cf8d53e532/ar0berts}, groups = {public}, interhash = {c549fb9a15404069e3e70b67b76efdb7}, intrahash = {f670f43faaf59096428c41cf8d53e532}, journal = {Arch Dis Child Fetal Neonatal Ed}, keywords = {Brain Diseases; Cause of Death; Cerebral Palsy; Diseases in Twins; England; Female; Fetal Fetofetal Transfusion; Follow-Up Studies; Gestational Age; Humans; Infant Mortality; Infant, Newborn; Male; Pregnancy; Prevalence; Risk Factors; Sex Factors}, month = Jan, number = 1, pages = {F9--15}, pmid = {11815541}, timestamp = {2014-07-19T19:33:20.000+0200}, title = {Fetal or infant death in twin pregnancy: neurodevelopmental consequence for the survivor.}, username = {ar0berts}, volume = 86, year = 2002 }