%0 Journal Article %1 LeFevre2009CycSiman %A Le Fèvre, F. %A Smidtas, S. %A Combe, C. %A Durot, M. %A d'Alché Buc, Florence %A Schachter, V. %B Bioinformatics %D 2009 %J Bioinformatics %K reconstruction software %N 15 %P 1987--1988 %R 10.1093/bioinformatics/btp268 %T CycSim—an online tool for exploring and experimenting with genome-scale metabolic models %U http://dx.doi.org/10.1093/bioinformatics/btp268 %V 25 %X Summary: CycSim is a web application dedicated to in silico experiments with genome-scale metabolic models coupled to the exploration of knowledge from BioCyc and KEGG. Specifically, CycSim supports the design of knockout experiments: simulation of growth phenotypes of single or multiple gene deletions mutants on specified media, comparison of these predictions with experimental phenotypes and direct visualization of both on metabolic maps. The web interface is designed for simplicity, putting constraint-based modelling techniques within easier reach of biologists. CycSim also functions as an online repository of genome-scale metabolic models.Availability: http://www.genoscope.cns.fr/cycsimContact: cycsim@genoscope.cns.fr

@article{LeFevre2009CycSiman, abstract = {Summary: {CycSim} is a web application dedicated to in silico experiments with genome-scale metabolic models coupled to the exploration of knowledge from {BioCyc} and {KEGG}. Specifically, {CycSim} supports the design of knockout experiments: simulation of growth phenotypes of single or multiple gene deletions mutants on specified media, comparison of these predictions with experimental phenotypes and direct visualization of both on metabolic maps. The web interface is designed for simplicity, putting constraint-based modelling techniques within easier reach of biologists. {CycSim} also functions as an online repository of genome-scale metabolic {models.Availability}: {http://www.genoscope.cns.fr/cycsimContact}: cycsim@genoscope.cns.fr}, added-at = {2018-12-02T16:09:07.000+0100}, author = {Le F\`{e}vre, F. and Smidtas, S. and Combe, C. and Durot, M. and d'Alch\'{e} Buc, Florence and Schachter, V.}, biburl = {https://www.bibsonomy.org/bibtex/24b689a567a9c746072dab4568612b88f/karthikraman}, booktitle = {Bioinformatics}, citeulike-article-id = {4510976}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/bioinformatics/btp268}, citeulike-linkout-1 = {http://bioinformatics.oxfordjournals.org/content/25/15/1987.abstract}, citeulike-linkout-2 = {http://bioinformatics.oxfordjournals.org/content/25/15/1987.full.pdf}, citeulike-linkout-3 = {http://bioinformatics.oxfordjournals.org/cgi/content/abstract/25/15/1987}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/19420054}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=19420054}, day = 1, doi = {10.1093/bioinformatics/btp268}, interhash = {ecc2569d1b841320b7259d79193e0f3b}, intrahash = {4b689a567a9c746072dab4568612b88f}, issn = {1367-4811}, journal = {Bioinformatics}, keywords = {reconstruction software}, month = aug, number = 15, pages = {1987--1988}, pmid = {19420054}, posted-at = {2009-11-11 14:43:38}, priority = {2}, timestamp = {2018-12-02T16:09:07.000+0100}, title = {{CycSim}—an online tool for exploring and experimenting with genome-scale metabolic models}, url = {http://dx.doi.org/10.1093/bioinformatics/btp268}, volume = 25, year = 2009 }