%0 Generic %1 mizukawa2013distinct %A Mizukawa, Y %A Iwasaka, M %D 2013 %K DNA Magnetic acid anisotropy base crystal crystallization diamagnetic nucleic rotation %T Distinct diamagnetic anisotropy in nucleic acid base crystals for bio-sensing applications %X Nucleic acids bases are important molecules and developing insight into their non-clarified properties should impact our understanding of not only molecular genetic biology but also magnetic material science. Studies have revealed the superconductivity of DNA under low temperature. Additionally, nucleic acid complexes, such as hydrogen bonded cytosine-guanine pairs, have been found to possess molecular magnetism with electron spin. Furthermore, it has been discovered that nucleic acid base crystals, such as guanine crystals, have a very thin structure with a distinct diamagnetic anisotropy. In the present study, for the purpose of developing a new bio-sensing device, the magnetically behaviours of the crystals of nucleic acid base and uric acid were investigated. We utilized adenine, cytosine and uric acid for the crystallization experiments. Real-time microscopic observations of artificially synthesized nucleic acid base crystal suspension were carried out under ambient fields and magnetic fields. The magnetic fields were generated by an electro-magnet at strength of 0.5 T. The observation of re-crystallized cytosine crystals was carried out with and without magnetic field exposures by utilizing a digital micro-scope. The magnetic orientation and structural color changes of the cytosine crystal was found. When artificial adenine crystals under magnetic fields were observed, the long axis of the artificial adenine crystals aligned perpendicular to the direction of magnetic fields. Also, uric acid crystals derived from guanine were investigated with and without magnetic fields. The magnetic orientation consisted of two phases in uric acid crystals was appeared. We revealed that the magnetic orientation of nucleic acid base crystals under magnetic fields was caused by diamagnetic susceptibility anisotropy. In particular, three kinds of crystals shared the feature aligning the long axis of crystals perpendicular to the direction of magnetic fields. It is speculated that three kinds of crystals responded to magnetic fields of 0.5 T due to crystal structures including six-membered ring. The methods obtained for detecting precise magnetic rotation in nucleic acid base crystals can be applied to the manipulation and sensing of macromolecules containing nucleic acid bases such as DNA and RNA.

@conference{mizukawa2013distinct, abstract = {Nucleic acids bases are important molecules and developing insight into their non-clarified properties should impact our understanding of not only molecular genetic biology but also magnetic material science. Studies have revealed the superconductivity of DNA under low temperature. Additionally, nucleic acid complexes, such as hydrogen bonded cytosine-guanine pairs, have been found to possess molecular magnetism with electron spin. Furthermore, it has been discovered that nucleic acid base crystals, such as guanine crystals, have a very thin structure with a distinct diamagnetic anisotropy. In the present study, for the purpose of developing a new bio-sensing device, the magnetically behaviours of the crystals of nucleic acid base and uric acid were investigated. We utilized adenine, cytosine and uric acid for the crystallization experiments. Real-time microscopic observations of artificially synthesized nucleic acid base crystal suspension were carried out under ambient fields and magnetic fields. The magnetic fields were generated by an electro-magnet at strength of 0.5 T. The observation of re-crystallized cytosine crystals was carried out with and without magnetic field exposures by utilizing a digital micro-scope. The magnetic orientation and structural color changes of the cytosine crystal was found. When artificial adenine crystals under magnetic fields were observed, the long axis of the artificial adenine crystals aligned perpendicular to the direction of magnetic fields. Also, uric acid crystals derived from guanine were investigated with and without magnetic fields. The magnetic orientation consisted of two phases in uric acid crystals was appeared. We revealed that the magnetic orientation of nucleic acid base crystals under magnetic fields was caused by diamagnetic susceptibility anisotropy. In particular, three kinds of crystals shared the feature aligning the long axis of crystals perpendicular to the direction of magnetic fields. It is speculated that three kinds of crystals responded to magnetic fields of 0.5 T due to crystal structures including six-membered ring. The methods obtained for detecting precise magnetic rotation in nucleic acid base crystals can be applied to the manipulation and sensing of macromolecules containing nucleic acid bases such as DNA and RNA.}, added-at = {2021-02-12T13:05:47.000+0100}, author = {Mizukawa, Y and Iwasaka, M}, biburl = {https://www.bibsonomy.org/bibtex/2601f7076925a83852714d47ff9c54d33/ceps}, interhash = {1f13cfc776ddff66ffb15c152f73f956}, intrahash = {601f7076925a83852714d47ff9c54d33}, keywords = {DNA Magnetic acid anisotropy base crystal crystallization diamagnetic nucleic rotation}, timestamp = {2023-12-21T08:29:09.000+0100}, title = {Distinct diamagnetic anisotropy in nucleic acid base crystals for bio-sensing applications}, year = 2013 }