Computer-based structural analysis of the ribosomal DNA intergenic
spacer (IGS) from the mosquito Aedes albopictus revealed a potential
to form strong and extensive secondary structures throughout a 4.7-kilobase
(kb) region. The predicted stability of secondary structures was
particularly high within a 3.15-kb region containing 17 tandem 201
base-pair subrepeats. Similarly strong secondary structure potential
was also found when IGS subrepeats were analyzed from 17 phylogenetically
diverse eukaryotes, including vertebrates, invertebrates, and plants.
Conservation of higher-order structure potential in the IGS region
of ribosomal DNA may reflect evolutionary and functional constraints
on chromatin organization, transcriptional regulation of the ribosomal
RNA genes, and/or transcript processing and stability.
%0 Journal Article
%1 Baldridge1992
%A Baldridge, G. D.
%A Dalton, M. W.
%A Fallon, A. M.
%D 1992
%J J Mol Evol
%K Acid Aedes, Animals; Base Conformation; DNA, Data; Molecular Nucleic Phylogeny; RNA, Ribosomal, Sequence Sequence; Species Specificity genetics;
%N 6
%P 514--523
%T Is higher-order structure conserved in eukaryotic ribosomal DNA intergenic
spacers?
%V 35
%X Computer-based structural analysis of the ribosomal DNA intergenic
spacer (IGS) from the mosquito Aedes albopictus revealed a potential
to form strong and extensive secondary structures throughout a 4.7-kilobase
(kb) region. The predicted stability of secondary structures was
particularly high within a 3.15-kb region containing 17 tandem 201
base-pair subrepeats. Similarly strong secondary structure potential
was also found when IGS subrepeats were analyzed from 17 phylogenetically
diverse eukaryotes, including vertebrates, invertebrates, and plants.
Conservation of higher-order structure potential in the IGS region
of ribosomal DNA may reflect evolutionary and functional constraints
on chromatin organization, transcriptional regulation of the ribosomal
RNA genes, and/or transcript processing and stability.
@article{Baldridge1992,
__markedentry = {[mdalton]},
abstract = {Computer-based structural analysis of the ribosomal DNA intergenic
spacer (IGS) from the mosquito Aedes albopictus revealed a potential
to form strong and extensive secondary structures throughout a 4.7-kilobase
(kb) region. The predicted stability of secondary structures was
particularly high within a 3.15-kb region containing 17 tandem 201
base-pair subrepeats. Similarly strong secondary structure potential
was also found when IGS subrepeats were analyzed from 17 phylogenetically
diverse eukaryotes, including vertebrates, invertebrates, and plants.
Conservation of higher-order structure potential in the IGS region
of ribosomal DNA may reflect evolutionary and functional constraints
on chromatin organization, transcriptional regulation of the ribosomal
RNA genes, and/or transcript processing and stability.},
added-at = {2010-06-02T20:45:31.000+0200},
author = {Baldridge, G. D. and Dalton, M. W. and Fallon, A. M.},
biburl = {https://www.bibsonomy.org/bibtex/20f0533f67f7f83d7891eb6e59d2ee7be/markwdalton},
description = {Marks Publications},
institution = {Department of Entomology, University of Minnesota, St. Paul 55108.},
interhash = {7c6c231235e6c5ab4b76d321bc413d84},
intrahash = {0f0533f67f7f83d7891eb6e59d2ee7be},
journal = {J Mol Evol},
keywords = {Acid Aedes, Animals; Base Conformation; DNA, Data; Molecular Nucleic Phylogeny; RNA, Ribosomal, Sequence Sequence; Species Specificity genetics;},
language = {eng},
medline-pst = {ppublish},
month = Dec,
number = 6,
owner = {mdalton},
pages = {514--523},
pmid = {1474605},
timestamp = {2010-06-02T20:45:31.000+0200},
title = {Is higher-order structure conserved in eukaryotic ribosomal DNA intergenic
spacers?},
volume = 35,
year = 1992
}