Despite thousands of reported patients with
pandemic-associated pernio, low rates of seroconversion and PCR positivity have defied causative
linkage to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Pernio in uninfected children
is associated with monogenic disorders of excessive
IFN-1 immunity, whereas severe COVID-19 pneumonia can result from insufficient IFN-1. Moreover,
SARS-CoV-2 spike protein and robust IFN-1 response
are seen in the skin of patients with pandemicassociated pernio, suggesting an excessive innate
immune skin response to SARS-CoV-2. Understanding the pathophysiology of this phenomenon may
elucidate the host mechanisms that drive a resilient
immune response to SARS-CoV-2 and could produce
relevant therapeutic targets.
Description
From Your Nose to Your Toes: A Review of Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic‒Associated Pernio
%0 Journal Article
%1 noauthororeditor
%A et al, Arkin
%D 2021
%J Journal of Investigative Dermatology
%K Covid-19
%R 10.1016/j.jid.2021.05.024
%T From Your Nose to Your Toes: A Review of Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic‒Associated Pernio
%U /brokenurl#10.1016/j.jid.2021.05.024
%X Despite thousands of reported patients with
pandemic-associated pernio, low rates of seroconversion and PCR positivity have defied causative
linkage to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Pernio in uninfected children
is associated with monogenic disorders of excessive
IFN-1 immunity, whereas severe COVID-19 pneumonia can result from insufficient IFN-1. Moreover,
SARS-CoV-2 spike protein and robust IFN-1 response
are seen in the skin of patients with pandemicassociated pernio, suggesting an excessive innate
immune skin response to SARS-CoV-2. Understanding the pathophysiology of this phenomenon may
elucidate the host mechanisms that drive a resilient
immune response to SARS-CoV-2 and could produce
relevant therapeutic targets.
@article{noauthororeditor,
abstract = {Despite thousands of reported patients with
pandemic-associated pernio, low rates of seroconversion and PCR positivity have defied causative
linkage to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Pernio in uninfected children
is associated with monogenic disorders of excessive
IFN-1 immunity, whereas severe COVID-19 pneumonia can result from insufficient IFN-1. Moreover,
SARS-CoV-2 spike protein and robust IFN-1 response
are seen in the skin of patients with pandemicassociated pernio, suggesting an excessive innate
immune skin response to SARS-CoV-2. Understanding the pathophysiology of this phenomenon may
elucidate the host mechanisms that drive a resilient
immune response to SARS-CoV-2 and could produce
relevant therapeutic targets.},
added-at = {2021-10-01T14:12:28.000+0200},
author = {et al, Arkin},
biburl = {https://www.bibsonomy.org/bibtex/210e9997f672c9cdb4d44afa8c5c07ab5/lkanth},
description = {From Your Nose to Your Toes: A Review of Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic‒Associated Pernio},
doi = {10.1016/j.jid.2021.05.024},
interhash = {1bc25c3a5caf865fe22cde02db0556e2},
intrahash = {10e9997f672c9cdb4d44afa8c5c07ab5},
journal = {Journal of Investigative Dermatology},
keywords = {Covid-19},
timestamp = {2021-10-01T14:12:28.000+0200},
title = {From Your Nose to Your Toes: A Review of Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic‒Associated Pernio},
url = {/brokenurl#10.1016/j.jid.2021.05.024},
year = 2021
}