A comparison of normalization methods for high density oligonucleotide array data based on variance and bias

, , , and . Bioinformatics 19 (2): 185-193 (January 2003)Evaluation Studies.


This article describes the normalization method used by Klein et al. on their data. Because they had no one method for normalizing ChIP-seq to start with, they tested several, and this was the one that gave the best results.

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