%0 Journal Article %1 Volpini1999 %A Volpini, R. %A Camaioni, E. %A Costanzi, S. %A Vittori, S. %A Klotz, K. N. %A Cristalli, G. %D 1999 %J Nucleosides Nucleotides %K & A2A A2B A3 Activation/drug Adenosine Adenosine/*analogs Adenylate Animals Assay CHO Cricetinae Cricetulus Cyclase/metabolism Enzyme Fusion Humans P1/*drug Proteins/drug Purinergic Radioligand Rats Recombinant Transfection derivatives/chemical effects effects/genetics synthesis/pharmacology Receptor Cell %N 11-12 %P 2511-20 %T Synthesis of di- and tri-substituted adenosine derivatives and their affinities at human adenosine receptor subtypes %U http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10639752 %V 18 %X The synthesis of 2-(hex-1-ynyl)adenosine derivatives substituted at the N6- and/or 5'-position was carried out on the basis that 2-(hex-1-ynyl)adenosine-5'-N-ethyluronamide (HENECA, 2) showed good affinity and different degree of selectivity for rat adenosine receptors. All new compounds were tested in radioligand binding and adenylyl cyclase assays with recently cloned human A1, A2A, A2B, and A3 adenosine receptors.

@article{Volpini1999, abstract = {The synthesis of 2-(hex-1-ynyl)adenosine derivatives substituted at the N6- and/or 5'-position was carried out on the basis that 2-(hex-1-ynyl)adenosine-5'-N-ethyluronamide (HENECA, 2) showed good affinity and different degree of selectivity for rat adenosine receptors. All new compounds were tested in radioligand binding and adenylyl cyclase assays with recently cloned human A1, A2A, A2B, and A3 adenosine receptors.}, added-at = {2010-12-14T18:12:02.000+0100}, author = {Volpini, R. and Camaioni, E. and Costanzi, S. and Vittori, S. and Klotz, K. N. and Cristalli, G.}, biburl = {https://www.bibsonomy.org/bibtex/225e41cef463e1338e38610bb5df54bae/pharmawuerz}, endnotereftype = {Journal Article}, interhash = {2490c77a97009de9b8bd75688cd34b30}, intrahash = {25e41cef463e1338e38610bb5df54bae}, issn = {0732-8311 (Print) 0732-8311 (Linking)}, journal = {Nucleosides Nucleotides}, keywords = {& A2A A2B A3 Activation/drug Adenosine Adenosine/*analogs Adenylate Animals Assay CHO Cricetinae Cricetulus Cyclase/metabolism Enzyme Fusion Humans P1/*drug Proteins/drug Purinergic Radioligand Rats Recombinant Transfection derivatives/chemical effects effects/genetics synthesis/pharmacology Receptor Cell}, month = {Nov-Dec}, note = {Volpini, R Camaioni, E Costanzi, S Vittori, S Klotz, K N Cristalli, G Comparative Study Research Support, Non-U.S. Gov't United states Nucleosides \& nucleotides Nucleosides Nucleotides. 1999 Nov-Dec;18(11-12):2511-20.}, number = {11-12}, pages = {2511-20}, shorttitle = {Synthesis of di- and tri-substituted adenosine derivatives and their affinities at human adenosine receptor subtypes}, timestamp = {2010-12-14T18:20:41.000+0100}, title = {Synthesis of di- and tri-substituted adenosine derivatives and their affinities at human adenosine receptor subtypes}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10639752}, volume = 18, year = 1999 }