%0 Journal Article %1 soto2016preliminary %A Soto, C. %A Saavedra, R. %A Toral, M.I. %A Nacaratte, F. %A Poza, C. %D 2016 %I 2016 Elsevier B.V. %J Microchemical Journal %K antimycotic, chromatography, ciclopirox derivatization, dqcauchile flow lens olamine, polarographic-determination, precolumn spectrometry, spectroscopy, thermal %P 36-40 %R 10.1016/j.microc.2016.06.004 %T Preliminary Studies for Ciclopirox Olamine Determination by Thermal Lens Spectrophotometry %U /brokenurl#<Go to ISI>://WOS:000382595300006 %V 129 %X The spectrophotometric kinetic methods are broadly used in the determination of drugs in several types of matrices. Thermal Lens Spectrometry (TLS) has demonstrated to be a sensitive indirect spectrophotometric technique used in the field of applied sciences, such as environmental and biochemical sciences. Ciclopirox olamine (OM) is a synthetic fungicide that inhibits the growth of pathogenic dermatophytes. This work presents the results of CXO determination by TLS, through a kinetic method, based on the CXO oxidation with KMnO4 in alkaline medium to form manganate (MnO42-). The Thermal Lens (TL) effect was generated by a He-Ne laser (TEM00, 20 mW, 632 nm). The TLS measurements were performed on a single beam assembly with a lens of f = 7.5 cm focal distance and 10 Hz modulation frequency. The TL signal from the detector was acquired for each sample. The optimization was at 30 min reaction time, KMnO4 8.0 . 10(-4) mol L-1 and Na2SO4 0.6 mol L-1. Under these conditions a calibration curve was constructed. The analytical features were LOD = 3.40 mu mol L-1 and LOQ = 113 mu mol L-1. To examine accuracy and reliability, the determination method was successfully applied in tap water samples where known amounts of CXO were spiked.

@article{soto2016preliminary, abstract = {The spectrophotometric kinetic methods are broadly used in the determination of drugs in several types of matrices. Thermal Lens Spectrometry (TLS) has demonstrated to be a sensitive indirect spectrophotometric technique used in the field of applied sciences, such as environmental and biochemical sciences. Ciclopirox olamine (OM) is a synthetic fungicide that inhibits the growth of pathogenic dermatophytes. This work presents the results of CXO determination by TLS, through a kinetic method, based on the CXO oxidation with KMnO4 in alkaline medium to form manganate (MnO42-). The Thermal Lens (TL) effect was generated by a He-Ne laser (TEM00, 20 mW, 632 nm). The TLS measurements were performed on a single beam assembly with a lens of f = 7.5 cm focal distance and 10 Hz modulation frequency. The TL signal from the detector was acquired for each sample. The optimization was at 30 min reaction time, KMnO4 8.0 . 10(-4) mol L-1 and Na2SO4 0.6 mol L-1. Under these conditions a calibration curve was constructed. The analytical features were LOD = 3.40 mu mol L-1 and LOQ = 113 mu mol L-1. To examine accuracy and reliability, the determination method was successfully applied in tap water samples where known amounts of CXO were spiked. }, added-at = {2019-12-04T03:57:35.000+0100}, author = {Soto, C. and Saavedra, R. and Toral, M.I. and Nacaratte, F. and Poza, C.}, biburl = {https://www.bibsonomy.org/bibtex/25598184307262cac101273031054ffc7/dqcauchile}, doi = {10.1016/j.microc.2016.06.004}, interhash = {a99efd0c26efc6f47cf790dd9525664c}, intrahash = {5598184307262cac101273031054ffc7}, issn = {0026-265x}, journal = {Microchemical Journal}, keywords = {antimycotic, chromatography, ciclopirox derivatization, dqcauchile flow lens olamine, polarographic-determination, precolumn spectrometry, spectroscopy, thermal}, pages = {36-40}, publisher = {2016 Elsevier B.V.}, timestamp = {2019-12-04T04:29:21.000+0100}, title = {Preliminary Studies for Ciclopirox Olamine Determination by Thermal Lens Spectrophotometry}, type = {Journal Article}, url = {/brokenurl#<Go to ISI>://WOS:000382595300006}, volume = 129, year = 2016 }