%0 Journal Article %1 Noushmehr:2010:Cancer-Cell:20399149 %A Noushmehr, H %A Weisenberger, D J %A Diefes, K %A Phillips, H S %A Pujara, K %A Berman, B P %A Pan, F %A Pelloski, C E %A Sulman, E P %A Bhat, K P %A Verhaak, R G %A Hoadley, K A %A Hayes, D N %A Perou, C M %A Schmidt, H K %A Ding, L %A Wilson, R K %A Van Den Berg, D %A Shen, H %A Bengtsson, H %A Neuvial, P %A Cope, L M %A Buckley, J %A Herman, J G %A Baylin, S B %A Laird, P W %A Aldape, K %A Cancer Genome Atlas Research Network, %D 2010 %J Cancer Cell %K %N 5 %P 510-522 %R 10.1016/j.ccr.2010.03.017 %T Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma %U https://www.ncbi.nlm.nih.gov/pubmed/?term=Identification%20of%20a%20CpG%20Island%20Methylator%20Phenotype%20that%20Defines%20a%20Distinct%20Subgroup%20of%20Glioma %V 17 %X We have profiled promoter DNA methylation alterations in 272 glioblastoma tumors in the context of The Cancer Genome Atlas (TCGA). We found that a distinct subset of samples displays concerted hypermethylation at a large number of loci, indicating the existence of a glioma-CpG island methylator phenotype (G-CIMP). We validated G-CIMP in a set of non-TCGA glioblastomas and low-grade gliomas. G-CIMP tumors belong to the proneural subgroup, are more prevalent among lower-grade gliomas, display distinct copy-number alterations, and are tightly associated with IDH1 somatic mutations. Patients with G-CIMP tumors are younger at the time of diagnosis and experience significantly improved outcome. These findings identify G-CIMP as a distinct subset of human gliomas on molecular and clinical grounds.

@article{Noushmehr:2010:Cancer-Cell:20399149, abstract = {We have profiled promoter DNA methylation alterations in 272 glioblastoma tumors in the context of The Cancer Genome Atlas (TCGA). We found that a distinct subset of samples displays concerted hypermethylation at a large number of loci, indicating the existence of a glioma-CpG island methylator phenotype (G-CIMP). We validated G-CIMP in a set of non-TCGA glioblastomas and low-grade gliomas. G-CIMP tumors belong to the proneural subgroup, are more prevalent among lower-grade gliomas, display distinct copy-number alterations, and are tightly associated with IDH1 somatic mutations. Patients with G-CIMP tumors are younger at the time of diagnosis and experience significantly improved outcome. These findings identify G-CIMP as a distinct subset of human gliomas on molecular and clinical grounds.}, added-at = {2017-10-07T21:58:41.000+0200}, author = {Noushmehr, H and Weisenberger, D J and Diefes, K and Phillips, H S and Pujara, K and Berman, B P and Pan, F and Pelloski, C E and Sulman, E P and Bhat, K P and Verhaak, R G and Hoadley, K A and Hayes, D N and Perou, C M and Schmidt, H K and Ding, L and Wilson, R K and Van Den Berg, D and Shen, H and Bengtsson, H and Neuvial, P and Cope, L M and Buckley, J and Herman, J G and Baylin, S B and Laird, P W and Aldape, K and {Cancer Genome Atlas Research Network}}, biburl = {https://www.bibsonomy.org/bibtex/28d46cd7fbe91c3387a3e66b70548f3f3/marcsaric}, doi = {10.1016/j.ccr.2010.03.017}, interhash = {25b6b0b94dd996854cab694d2b468135}, intrahash = {8d46cd7fbe91c3387a3e66b70548f3f3}, journal = {Cancer Cell}, keywords = {}, month = may, number = 5, pages = {510-522}, pmid = {20399149}, timestamp = {2017-10-07T21:58:41.000+0200}, title = {Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma}, url = {https://www.ncbi.nlm.nih.gov/pubmed/?term=Identification%20of%20a%20CpG%20Island%20Methylator%20Phenotype%20that%20Defines%20a%20Distinct%20Subgroup%20of%20Glioma}, volume = 17, year = 2010 }