A post-ischaemic single administration of galanthamine, a cholinesterase
inhibitor, improves learning ability in rats
A. Iliev, V. Traykov, G. Mantchev, I. Stoykov, D. Prodanov, K. Yakimova, and I. Krushkov. J Pharm Pharmacol, 52 (9):
1151-6(September 2000)Iliev, A I Traykov, V B Mantchev, G T Stoykov, I Prodanov, D Yakimova,
K S Krushkov, I M England The Journal of pharmacy and pharmacology
J Pharm Pharmacol. 2000 Sep;52(9):1151-6..
Abstract
Transient forebrain ischaemia is widely observed in clinical practice.
We have examined the effect of a single administration of the cholinesterase
inhibitor galanthamine (2mg kg(-1) i.p.) 25 min after reperfusion
in male Sprague-Dawley rats (180 +/- 20 g) after a 20-min common
carotid artery occlusion. Twenty-four-hours post-ischaemia there
was no difference in motor co-ordination or muscle tonus of the rats
treated with or without galanthamine as assessed by the rota-rod
test. Learning ability was examined using the shuttle-box test, evaluating
the latency time and the number of errors for six days in succession.
The performance of the ischaemic saline-injected rats was significantly
impaired on days 4, 5, 6 (latency time) compared with the non-ischaemic
rats and with the ischaemic animals administered galanthamine (P
< 0.05). Similar results were obtained when counting the number of
errors (failure to cross the cage during conditioned or unconditioned
stimulus). The monitoring of body temperature during the first 12-h
post-ischaemia did not show any significant difference between the
groups. The data showed a beneficial effect of galanthamine on the
recovery of learning ability when administered once only post-ischaemia.
This suggests a direct effect on the early pathologic mechanisms
of CNS damage. Cholinesterase inhibitors may prove useful in the
early clinical treatment of ischaemic conditions.
Iliev, A I Traykov, V B Mantchev, G T Stoykov, I Prodanov, D Yakimova,
K S Krushkov, I M England The Journal of pharmacy and pharmacology
J Pharm Pharmacol. 2000 Sep;52(9):1151-6.
%0 Journal Article
%1 Iliev2000
%A Iliev, A. I.
%A Traykov, V. B.
%A Mantchev, G. T.
%A Stoykov, I.
%A Prodanov, D.
%A Yakimova, K. S.
%A Krushkov, I. M.
%D 2000
%J J Pharm Pharmacol
%K Animals Attack, Cholinesterase Galantamine/*therapeutic Inhibitors/*therapeutic Ischemic Learning/*drug Male Rats Sprague-Dawley Transient/*drug effects therapy use
%N 9
%P 1151-6
%T A post-ischaemic single administration of galanthamine, a cholinesterase
inhibitor, improves learning ability in rats
%U http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11045897
%V 52
%X Transient forebrain ischaemia is widely observed in clinical practice.
We have examined the effect of a single administration of the cholinesterase
inhibitor galanthamine (2mg kg(-1) i.p.) 25 min after reperfusion
in male Sprague-Dawley rats (180 +/- 20 g) after a 20-min common
carotid artery occlusion. Twenty-four-hours post-ischaemia there
was no difference in motor co-ordination or muscle tonus of the rats
treated with or without galanthamine as assessed by the rota-rod
test. Learning ability was examined using the shuttle-box test, evaluating
the latency time and the number of errors for six days in succession.
The performance of the ischaemic saline-injected rats was significantly
impaired on days 4, 5, 6 (latency time) compared with the non-ischaemic
rats and with the ischaemic animals administered galanthamine (P
< 0.05). Similar results were obtained when counting the number of
errors (failure to cross the cage during conditioned or unconditioned
stimulus). The monitoring of body temperature during the first 12-h
post-ischaemia did not show any significant difference between the
groups. The data showed a beneficial effect of galanthamine on the
recovery of learning ability when administered once only post-ischaemia.
This suggests a direct effect on the early pathologic mechanisms
of CNS damage. Cholinesterase inhibitors may prove useful in the
early clinical treatment of ischaemic conditions.
@article{Iliev2000,
abstract = {Transient forebrain ischaemia is widely observed in clinical practice.
We have examined the effect of a single administration of the cholinesterase
inhibitor galanthamine (2mg kg(-1) i.p.) 25 min after reperfusion
in male Sprague-Dawley rats (180 +/- 20 g) after a 20-min common
carotid artery occlusion. Twenty-four-hours post-ischaemia there
was no difference in motor co-ordination or muscle tonus of the rats
treated with or without galanthamine as assessed by the rota-rod
test. Learning ability was examined using the shuttle-box test, evaluating
the latency time and the number of errors for six days in succession.
The performance of the ischaemic saline-injected rats was significantly
impaired on days 4, 5, 6 (latency time) compared with the non-ischaemic
rats and with the ischaemic animals administered galanthamine (P
< 0.05). Similar results were obtained when counting the number of
errors (failure to cross the cage during conditioned or unconditioned
stimulus). The monitoring of body temperature during the first 12-h
post-ischaemia did not show any significant difference between the
groups. The data showed a beneficial effect of galanthamine on the
recovery of learning ability when administered once only post-ischaemia.
This suggests a direct effect on the early pathologic mechanisms
of CNS damage. Cholinesterase inhibitors may prove useful in the
early clinical treatment of ischaemic conditions.},
added-at = {2010-12-14T18:12:02.000+0100},
author = {Iliev, A. I. and Traykov, V. B. and Mantchev, G. T. and Stoykov, I. and Prodanov, D. and Yakimova, K. S. and Krushkov, I. M.},
biburl = {https://www.bibsonomy.org/bibtex/25b7a11839a77bd32bf54b0db9c797214/pharmawuerz},
endnotereftype = {Journal Article},
interhash = {7387d2250146fe403288f76f499f92c3},
intrahash = {5b7a11839a77bd32bf54b0db9c797214},
issn = {0022-3573 (Print) 0022-3573 (Linking)},
journal = {J Pharm Pharmacol},
keywords = {Animals Attack, Cholinesterase Galantamine/*therapeutic Inhibitors/*therapeutic Ischemic Learning/*drug Male Rats Sprague-Dawley Transient/*drug effects therapy use},
month = Sep,
note = {Iliev, A I Traykov, V B Mantchev, G T Stoykov, I Prodanov, D Yakimova,
K S Krushkov, I M England The Journal of pharmacy and pharmacology
J Pharm Pharmacol. 2000 Sep;52(9):1151-6.},
number = 9,
pages = {1151-6},
shorttitle = {A post-ischaemic single administration of galanthamine, a cholinesterase
inhibitor, improves learning ability in rats},
timestamp = {2010-12-14T18:22:56.000+0100},
title = {A post-ischaemic single administration of galanthamine, a cholinesterase
inhibitor, improves learning ability in rats},
url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11045897},
volume = 52,
year = 2000
}