Nucleic acids bases are important molecules and developing insight into their non-clarified
properties should impact our understanding of not only molecular genetic biology but also magnetic
material science. Studies have revealed the superconductivity of DNA under low temperature.
Additionally, nucleic acid complexes, such as hydrogen bonded cytosine-guanine pairs, have been
found to possess molecular magnetism with electron spin. Furthermore, it has been discovered that
nucleic acid base crystals, such as guanine crystals, have a very thin structure with a distinct
diamagnetic anisotropy.
In the present study, for the purpose of developing a new bio-sensing device, the magnetically
behaviours of the crystals of nucleic acid base and uric acid were investigated. We utilized adenine,
cytosine and uric acid for the crystallization experiments. Real-time microscopic observations of
artificially synthesized nucleic acid base crystal suspension were carried out under ambient fields and
magnetic fields. The magnetic fields were generated by an electro-magnet at strength of 0.5 T.
The observation of re-crystallized cytosine crystals was carried out with and without magnetic
field exposures by utilizing a digital micro-scope. The magnetic orientation and structural color
changes of the cytosine crystal was found. When artificial adenine crystals under magnetic fields were
observed, the long axis of the artificial adenine crystals aligned perpendicular to the direction of
magnetic fields. Also, uric acid crystals derived from guanine were investigated with and without
magnetic fields. The magnetic orientation consisted of two phases in uric acid crystals was appeared.
We revealed that the magnetic orientation of nucleic acid base crystals under magnetic fields
was caused by diamagnetic susceptibility anisotropy. In particular, three kinds of crystals shared the
feature aligning the long axis of crystals perpendicular to the direction of magnetic fields. It is
speculated that three kinds of crystals responded to magnetic fields of 0.5 T due to crystal structures
including six-membered ring. The methods obtained for detecting precise magnetic rotation in nucleic
acid base crystals can be applied to the manipulation and sensing of macromolecules containing
nucleic acid bases such as DNA and RNA.
%0 Generic
%1 mizukawa2013distinct
%A Mizukawa, Y
%A Iwasaka, M
%D 2013
%K DNA acid anisotropy base crystal crystallization diamagnetic magnetic nucleic rotation
%T Distinct diamagnetic anisotropy
in nucleic acid base crystals for bio-sensing applications
%X Nucleic acids bases are important molecules and developing insight into their non-clarified
properties should impact our understanding of not only molecular genetic biology but also magnetic
material science. Studies have revealed the superconductivity of DNA under low temperature.
Additionally, nucleic acid complexes, such as hydrogen bonded cytosine-guanine pairs, have been
found to possess molecular magnetism with electron spin. Furthermore, it has been discovered that
nucleic acid base crystals, such as guanine crystals, have a very thin structure with a distinct
diamagnetic anisotropy.
In the present study, for the purpose of developing a new bio-sensing device, the magnetically
behaviours of the crystals of nucleic acid base and uric acid were investigated. We utilized adenine,
cytosine and uric acid for the crystallization experiments. Real-time microscopic observations of
artificially synthesized nucleic acid base crystal suspension were carried out under ambient fields and
magnetic fields. The magnetic fields were generated by an electro-magnet at strength of 0.5 T.
The observation of re-crystallized cytosine crystals was carried out with and without magnetic
field exposures by utilizing a digital micro-scope. The magnetic orientation and structural color
changes of the cytosine crystal was found. When artificial adenine crystals under magnetic fields were
observed, the long axis of the artificial adenine crystals aligned perpendicular to the direction of
magnetic fields. Also, uric acid crystals derived from guanine were investigated with and without
magnetic fields. The magnetic orientation consisted of two phases in uric acid crystals was appeared.
We revealed that the magnetic orientation of nucleic acid base crystals under magnetic fields
was caused by diamagnetic susceptibility anisotropy. In particular, three kinds of crystals shared the
feature aligning the long axis of crystals perpendicular to the direction of magnetic fields. It is
speculated that three kinds of crystals responded to magnetic fields of 0.5 T due to crystal structures
including six-membered ring. The methods obtained for detecting precise magnetic rotation in nucleic
acid base crystals can be applied to the manipulation and sensing of macromolecules containing
nucleic acid bases such as DNA and RNA.
@conference{mizukawa2013distinct,
abstract = {Nucleic acids bases are important molecules and developing insight into their non-clarified
properties should impact our understanding of not only molecular genetic biology but also magnetic
material science. Studies have revealed the superconductivity of DNA under low temperature.
Additionally, nucleic acid complexes, such as hydrogen bonded cytosine-guanine pairs, have been
found to possess molecular magnetism with electron spin. Furthermore, it has been discovered that
nucleic acid base crystals, such as guanine crystals, have a very thin structure with a distinct
diamagnetic anisotropy.
In the present study, for the purpose of developing a new bio-sensing device, the magnetically
behaviours of the crystals of nucleic acid base and uric acid were investigated. We utilized adenine,
cytosine and uric acid for the crystallization experiments. Real-time microscopic observations of
artificially synthesized nucleic acid base crystal suspension were carried out under ambient fields and
magnetic fields. The magnetic fields were generated by an electro-magnet at strength of 0.5 T.
The observation of re-crystallized cytosine crystals was carried out with and without magnetic
field exposures by utilizing a digital micro-scope. The magnetic orientation and structural color
changes of the cytosine crystal was found. When artificial adenine crystals under magnetic fields were
observed, the long axis of the artificial adenine crystals aligned perpendicular to the direction of
magnetic fields. Also, uric acid crystals derived from guanine were investigated with and without
magnetic fields. The magnetic orientation consisted of two phases in uric acid crystals was appeared.
We revealed that the magnetic orientation of nucleic acid base crystals under magnetic fields
was caused by diamagnetic susceptibility anisotropy. In particular, three kinds of crystals shared the
feature aligning the long axis of crystals perpendicular to the direction of magnetic fields. It is
speculated that three kinds of crystals responded to magnetic fields of 0.5 T due to crystal structures
including six-membered ring. The methods obtained for detecting precise magnetic rotation in nucleic
acid base crystals can be applied to the manipulation and sensing of macromolecules containing
nucleic acid bases such as DNA and RNA.},
added-at = {2021-02-12T12:13:25.000+0100},
author = {Mizukawa, Y and Iwasaka, M},
biburl = {https://www.bibsonomy.org/bibtex/2601f7076925a83852714d47ff9c54d33/chkokalis},
interhash = {1f13cfc776ddff66ffb15c152f73f956},
intrahash = {601f7076925a83852714d47ff9c54d33},
keywords = {DNA acid anisotropy base crystal crystallization diamagnetic magnetic nucleic rotation},
timestamp = {2021-02-12T16:11:24.000+0100},
title = {Distinct diamagnetic anisotropy
in nucleic acid base crystals for bio-sensing applications},
year = 2013
}