Of 45 Russian patients with late complement component deficiency (LCCD) who experienced one to five meningococcal infections, 31 were immunised with a meningococcal A/C/W135/Y polysaccharide vaccine and were followed for 3-8 years. Total and immunoglobulin (Ig) class specific concentration of antibodies to meningococcal polysaccharides in sera of LCCD patients increased significantly 1 month after vaccination and remained elevated for 3 years. Revaccination of LCCD patients 3 years after the first dose restored the total Ig concentrations to those observed 1 year after the first vaccination. Six new episodes of meningococcal infection in four patients developed in the group of 31 vaccinees; six episodes in six patients developed in the same time in the group of 14 non-vaccinated LCCD persons. Survival analysis demonstrated the risk to contract meningococcal disease decreased significantly for vaccinees in comparison to non-vaccinees (P\textless0.05). Vaccination with of meningococcal tetravalent polysaccharide vaccine decreases the risk of meningococcal infection in LCCD patients.
%0 Journal Article
%1 platonov_long_2003
%A Platonov, Alexander E
%A Vershinina, Irina V
%A Kuijper, Edward J
%A Borrow, Ray
%A Käyhty, Helena
%D 2003
%J Vaccine
%K A, Adult, Antibodies, Bacterial, Chain Complement Female, G, Humans, Immunization, Immunoglobulin Kinetics, Lipopolysaccharides, M, Male, Meningitis, Meningococcal Meningococcal, Polymerase Proteins, Reaction, Reverse Secondary, Serotyping, Studies, System Transcriptase Vaccination Vaccines, {Follow-Up}
%N 27-30
%P 4437--4447
%T Long term effects of vaccination of patients deficient in a late complement component with a tetravalent meningococcal polysaccharide vaccine
%U http://www.ncbi.nlm.nih.gov/pubmed/14505927
%V 21
%X Of 45 Russian patients with late complement component deficiency (LCCD) who experienced one to five meningococcal infections, 31 were immunised with a meningococcal A/C/W135/Y polysaccharide vaccine and were followed for 3-8 years. Total and immunoglobulin (Ig) class specific concentration of antibodies to meningococcal polysaccharides in sera of LCCD patients increased significantly 1 month after vaccination and remained elevated for 3 years. Revaccination of LCCD patients 3 years after the first dose restored the total Ig concentrations to those observed 1 year after the first vaccination. Six new episodes of meningococcal infection in four patients developed in the group of 31 vaccinees; six episodes in six patients developed in the same time in the group of 14 non-vaccinated LCCD persons. Survival analysis demonstrated the risk to contract meningococcal disease decreased significantly for vaccinees in comparison to non-vaccinees (P\textless0.05). Vaccination with of meningococcal tetravalent polysaccharide vaccine decreases the risk of meningococcal infection in LCCD patients.
@article{platonov_long_2003,
abstract = {Of 45 Russian patients with late complement component deficiency {(LCCD)} who experienced one to five meningococcal infections, 31 were immunised with a meningococcal {A/C/W135/Y} polysaccharide vaccine and were followed for 3-8 years. Total and immunoglobulin {(Ig)} class specific concentration of antibodies to meningococcal polysaccharides in sera of {LCCD} patients increased significantly 1 month after vaccination and remained elevated for 3 years. Revaccination of {LCCD} patients 3 years after the first dose restored the total Ig concentrations to those observed 1 year after the first vaccination. Six new episodes of meningococcal infection in four patients developed in the group of 31 vaccinees; six episodes in six patients developed in the same time in the group of 14 non-vaccinated {LCCD} persons. Survival analysis demonstrated the risk to contract meningococcal disease decreased significantly for vaccinees in comparison to non-vaccinees {(P{\textless}0.05).} Vaccination with of meningococcal tetravalent polysaccharide vaccine decreases the risk of meningococcal infection in {LCCD} patients.},
added-at = {2011-03-11T10:05:34.000+0100},
author = {Platonov, Alexander E and Vershinina, Irina V and Kuijper, Edward J and Borrow, Ray and Käyhty, Helena},
biburl = {https://www.bibsonomy.org/bibtex/29c677ce3866336150b9d689349014d07/jelias},
interhash = {c6d09bfddbc4d68da31ebce423aa78f9},
intrahash = {9c677ce3866336150b9d689349014d07},
issn = {{0264-410X}},
journal = {Vaccine},
keywords = {A, Adult, Antibodies, Bacterial, Chain Complement Female, G, Humans, Immunization, Immunoglobulin Kinetics, Lipopolysaccharides, M, Male, Meningitis, Meningococcal Meningococcal, Polymerase Proteins, Reaction, Reverse Secondary, Serotyping, Studies, System Transcriptase Vaccination Vaccines, {Follow-Up}},
month = oct,
note = {{PMID:} 14505927},
number = {27-30},
pages = {4437--4447},
timestamp = {2011-03-11T10:06:14.000+0100},
title = {Long term effects of vaccination of patients deficient in a late complement component with a tetravalent meningococcal polysaccharide vaccine},
url = {http://www.ncbi.nlm.nih.gov/pubmed/14505927},
volume = 21,
year = 2003
}