We describe the epidemiology of invasive meningococcal disease in South Africa from August 1999 through July 2002, as reported to a laboratory-based surveillance system. Neisseria meningitidis isolates were further characterized. In total, 854 cases of laboratory-confirmed disease were reported, with an annual incidence rate of 0.64/100,000 population. Incidence was highest in infants \textless 1 year of age. Serogroup B caused 41\% of cases; serogroup A, 23\%; serogroup Y, 21\%; serogroup C, 8\%; and serogroup W135, 5\%. Serogroup B was the predominant serogroup in Western Cape Province, and disease rates remained stable. Serogroup A was most prevalent in Gauteng Province and increased over the 3 years. On pulsed-field gel electrophoresis analysis, serogroup A strains showed clonality, and serogroup B demonstrated considerable diversity. Selected isolates of serogroup A belonged to sequence type (ST)-1 (subgroup I/II) complex, serogroup B to ST-32/electrophoretic type (ET)-5 complex, and serogroup W135 to ST-11/ET-37 complex.
%0 Journal Article
%1 coulson_meningococcal_2007
%A Coulson, Garry B
%A von Gottberg, Anne
%A du Plessis, Mignon
%A Smith, Anthony M
%A de Gouveia, Linda
%A Klugman, Keith P
%D 2007
%J Emerging Infectious Diseases
%K Africa Epidemiology, Humans, Infections, Meningococcal Molecular, Neisseria Serotyping, South meningitidis,
%N 2
%P 273--281
%T Meningococcal disease in South Africa, 1999-2002
%U http://www.ncbi.nlm.nih.gov/pubmed/17479891
%V 13
%X We describe the epidemiology of invasive meningococcal disease in South Africa from August 1999 through July 2002, as reported to a laboratory-based surveillance system. Neisseria meningitidis isolates were further characterized. In total, 854 cases of laboratory-confirmed disease were reported, with an annual incidence rate of 0.64/100,000 population. Incidence was highest in infants \textless 1 year of age. Serogroup B caused 41\% of cases; serogroup A, 23\%; serogroup Y, 21\%; serogroup C, 8\%; and serogroup W135, 5\%. Serogroup B was the predominant serogroup in Western Cape Province, and disease rates remained stable. Serogroup A was most prevalent in Gauteng Province and increased over the 3 years. On pulsed-field gel electrophoresis analysis, serogroup A strains showed clonality, and serogroup B demonstrated considerable diversity. Selected isolates of serogroup A belonged to sequence type (ST)-1 (subgroup I/II) complex, serogroup B to ST-32/electrophoretic type (ET)-5 complex, and serogroup W135 to ST-11/ET-37 complex.
@article{coulson_meningococcal_2007,
abstract = {We describe the epidemiology of invasive meningococcal disease in South Africa from August 1999 through July 2002, as reported to a laboratory-based surveillance system. Neisseria meningitidis isolates were further characterized. In total, 854 cases of laboratory-confirmed disease were reported, with an annual incidence rate of 0.64/100,000 population. Incidence was highest in infants {\textless} 1 year of age. Serogroup B caused 41\% of cases; serogroup A, 23\%; serogroup Y, 21\%; serogroup C, 8\%; and serogroup W135, 5\%. Serogroup B was the predominant serogroup in Western Cape Province, and disease rates remained stable. Serogroup A was most prevalent in Gauteng Province and increased over the 3 years. On pulsed-field gel electrophoresis analysis, serogroup A strains showed clonality, and serogroup B demonstrated considerable diversity. Selected isolates of serogroup A belonged to sequence type {(ST)-1} (subgroup {I/II)} complex, serogroup B to {ST-32/electrophoretic} type {(ET)-5} complex, and serogroup W135 to {ST-11/ET-37} complex.},
added-at = {2011-03-11T10:05:34.000+0100},
author = {Coulson, Garry B and von Gottberg, Anne and du Plessis, Mignon and Smith, Anthony M and de Gouveia, Linda and Klugman, Keith P},
biburl = {https://www.bibsonomy.org/bibtex/2a25d43663ee3f37afcf1a4caaa477ebc/jelias},
interhash = {1375a99782f008673a7c05341dcf4304},
intrahash = {a25d43663ee3f37afcf1a4caaa477ebc},
issn = {1080-6040},
journal = {Emerging Infectious Diseases},
keywords = {Africa Epidemiology, Humans, Infections, Meningococcal Molecular, Neisseria Serotyping, South meningitidis,},
month = feb,
note = {{PMID:} 17479891},
number = 2,
pages = {273--281},
timestamp = {2011-03-11T10:06:26.000+0100},
title = {Meningococcal disease in South Africa, 1999-2002},
url = {http://www.ncbi.nlm.nih.gov/pubmed/17479891},
volume = 13,
year = 2007
}