Abstract
Our aim was to establish parameters describing systolic and diastolic
function in mice after myocardial infarction (MI) that distinguish
MI with pulmonary congestion from MI without congestion. Echocardiography,
left ventricular (LV) catheterization, and infarct size measurements
were performed on days 3, 5, 7, and 14 after ligation of the left
coronary artery in C57BL/6 mice. Sham-operated mice were used as
controls (Sham). MI mice with lung weight normalized to tibial
length >125\% of the average in the corresponding Sham group were
considered to have pulmonary congestion (MIchf). MI mice with
a smaller increase were called MI nonfailing (MInf). An infarct
>40\% of total LV circumference measured in two-dimensional long
axis distinguished MIchf from MInf on both an average and an
individual basis. Mean maximum rate of rise of LV pressure, LV
fractional shortening, and posterior wall shortening velocity were
significantly lower in MIchf compared with Sham at all time points
and to MInf at 7 days. The diastolic parameters mitral flow deceleration
velocity, LV end-diastolic pressure, and maximum rate of decline
in LV pressure (LVdP/dtmin) discriminated the MIchf groups
from Sham at all time points. Mitral flow deceleration velocity and
LVdP/dtmin separated MIchf from MInf at 7 days. In addition
to distinguishing all the groups on an average basis, left atrial
diameter distinguished all MIchf animals from Sham and MInf.
In conclusion, significantly increased left atrial diameter and infarct
size >40\% of total LV circumference may serve as major criteria
for heart failure with pulmonary congestion after MI in mice.
- 15475595
- and
- animals,
- c57bl,
- comparative
- computer-assisted,
- congestive,
- diagnosis,
- differential,
- doppler,
- dysfunction,
- echocardiography,
- edema,
- failure,
- female,
- gov't,
- heart
- illness
- image
- inbred
- index,
- infarction,
- interpretation,
- left,
- mice,
- myocardial
- non-u.s.
- of
- pulmonary
- pulsed,
- reproducibility
- research
- results,
- sensitivity
- severity
- specificity,
- study,
- support,
- ventricular
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