Аннотация
A computational model of the human left-ventricular epicardial myocyte
is presented. Models of each of the major ionic currents present
in these cells are formulated and validated using experimental data
obtained from studies of recombinant human ion channels and/or whole-cell
recording from single myocytes isolated from human left-ventricular
subepicardium. Continuous-time Markov chain models for the gating
of the fast Na$^+$ current, transient outward current, rapid
component of the delayed rectifier current, and the L-type calcium
current are modified to represent human data at physiological temperature.
A new model for the gating of the slow component of the delayed rectifier
current is formulated and validated against experimental data. Properties
of calcium handling and exchanger currents are altered to appropriately
represent the dynamics of intracellular ion concentrations. The model
is able to both reproduce and predict a wide range of behaviors observed
experimentally including action potential morphology, ionic currents,
intracellular calcium transients, frequency dependence of action-potential
duration, Ca$^2+$-frequency relations, and extrasystolic restitution/post-extrasystolic
potentiation. The model therefore serves as a useful tool for investigating
mechanisms of arrhythmia and consequences of drug-channel interactions
in the human left-ventricular myocyte.
- 15345532
- algorithms,
- arrhythmia,
- atpase,
- biophysics,
- calcium
- calcium,
- chains,
- channels,
- factors,
- gov't,
- heart
- humans,
- ions,
- kinetics,
- markov
- models,
- non-u.s.
- p.h.s.,
- potassium,
- research
- sodium,
- software,
- statistical,
- support,
- theoretical,
- time
- u.s.
- ventricles,
- {c}a$^{2+}$-transporting
Пользователи данного ресурса
Пожалуйста,
войдите в систему, чтобы принять участие в дискуссии (добавить собственные рецензию, или комментарий)