In vitro and in vivo assessment of linezolid combined with ertapenem: a highly synergistic combination against methicillin-resistant Staphylococcus aureus.
Linezolid in combination with ertapenem showed in vitro synergy against methicillin-resistant Staphylococcus aureus strains. We confirmed this interaction in vivo by using a rabbit endocarditis experimental model and simulation of the human pharmacokinetics in animals for both antibiotics. Linezolid plus ertapenem exhibited highly synergistic activity in vivo after 4 days of treatment.
%0 Journal Article
%1 Jacqueline2006
%A Jacqueline, Cedric
%A Caillon, Jocelyne
%A Grossi, Olivier
%A Le Mabecque, Virginie
%A Miegeville, Anne-Françoise
%A Bugnon, Denis
%A Batard, Eric
%A Potel, Gilles
%D 2006
%J Antimicrob Agents Chemother
%K endocarditis
%N 7
%P 2547--2549
%R 10.1128/AAC.01501-05
%T In vitro and in vivo assessment of linezolid combined with ertapenem: a highly synergistic combination against methicillin-resistant Staphylococcus aureus.
%U http://dx.doi.org/10.1128/AAC.01501-05
%V 50
%X Linezolid in combination with ertapenem showed in vitro synergy against methicillin-resistant Staphylococcus aureus strains. We confirmed this interaction in vivo by using a rabbit endocarditis experimental model and simulation of the human pharmacokinetics in animals for both antibiotics. Linezolid plus ertapenem exhibited highly synergistic activity in vivo after 4 days of treatment.
@article{Jacqueline2006,
abstract = {Linezolid in combination with ertapenem showed in vitro synergy against methicillin-resistant Staphylococcus aureus strains. We confirmed this interaction in vivo by using a rabbit endocarditis experimental model and simulation of the human pharmacokinetics in animals for both antibiotics. Linezolid plus ertapenem exhibited highly synergistic activity in vivo after 4 days of treatment.},
added-at = {2012-02-28T22:13:56.000+0100},
author = {Jacqueline, Cedric and Caillon, Jocelyne and Grossi, Olivier and {Le Mabecque}, Virginie and Miegeville, Anne-Françoise and Bugnon, Denis and Batard, Eric and Potel, Gilles},
biburl = {https://www.bibsonomy.org/bibtex/2c1b14d769a5395cb45c96b6903336dd3/aorchid},
doi = {10.1128/AAC.01501-05},
groups = {public},
institution = {Laboratoire d'Antibiologie (UPRES EA 3826), UER de Médecine, 44035 Nantes, Cedex 01, France.},
interhash = {088301fb459eaeaa49753923c69f1692},
intrahash = {c1b14d769a5395cb45c96b6903336dd3},
journal = {Antimicrob Agents Chemother},
keywords = {endocarditis},
language = {eng},
medline-pst = {ppublish},
month = Jul,
number = 7,
pages = {2547--2549},
pii = {50/7/2547},
pmid = {16801442},
timestamp = {2012-02-28T22:13:56.000+0100},
title = {In vitro and in vivo assessment of linezolid combined with ertapenem: a highly synergistic combination against methicillin-resistant Staphylococcus aureus.},
url = {http://dx.doi.org/10.1128/AAC.01501-05},
username = {aorchid},
volume = 50,
year = 2006
}