We report the results of a 5-year prospective cohort study of risk factors for fractures, including drinking fluoridated water, in a cohort of 3,216 men and women aged 65 years and older. We studied risk factors for hip fracture and fractures at other locations separately. We found a higher risk of hip fractures for subjects exposed to fluorine concentrations over 0.11 mg per liter but without a dose-effect relation (odds ratio (OR) = 3.25 for a concentration of 0.11-0.25 mg per liter; OR = 2.43 for > or = 0.25 mg per liter. For higher thresholds (0.7 and 1 mg per liter), however, the OR was less than 1. We found no association between fluorine and non-hip fractures. Non-hip fractures were associated with polymedication rather than with specific drug use, whereas fracture was associated with polymedication and use of anxiolytic and antidepressive drugs. Subjects drinking spirits every day were more likely to have hip fractures. Tobacco consumption increased the risk for non-hip fractures.
%0 Journal Article
%1 JacqminGadda1998
%A Jacqmin-Gadda, H
%A Fourrier, A
%A Commenges, D
%A Dartigues, J F
%D 1998
%J Epidemiology (Cambridge, Mass.)
%K 80andover AgeFactors Aged AlcoholDrinking AlcoholDrinking:epidemiology BodyMassIndex Bone Bone:epidemiology ConfidenceIntervals Female Fluoridation Fluoridation:adverseeffects Fluoridation:statistics&numericaldata Fluorine Fluorine:adverseeffects Fractures France France:epidemiology HealthSurveys HipFractures HipFractures:epidemiology Humans LogisticModels Male MultivariateAnalysis OddsRatio Polypharmacy ProspectiveStudies PsychotropicDrugs PsychotropicDrugs:adverseeffects RiskFactors SamplingStudies SexFactors Smoking Smoking:epidemiology
%N 4
%P 417-23
%T Risk factors for fractures in the elderly.
%U http://www.ncbi.nlm.nih.gov/pubmed/9647906
%V 9
%X We report the results of a 5-year prospective cohort study of risk factors for fractures, including drinking fluoridated water, in a cohort of 3,216 men and women aged 65 years and older. We studied risk factors for hip fracture and fractures at other locations separately. We found a higher risk of hip fractures for subjects exposed to fluorine concentrations over 0.11 mg per liter but without a dose-effect relation (odds ratio (OR) = 3.25 for a concentration of 0.11-0.25 mg per liter; OR = 2.43 for > or = 0.25 mg per liter. For higher thresholds (0.7 and 1 mg per liter), however, the OR was less than 1. We found no association between fluorine and non-hip fractures. Non-hip fractures were associated with polymedication rather than with specific drug use, whereas fracture was associated with polymedication and use of anxiolytic and antidepressive drugs. Subjects drinking spirits every day were more likely to have hip fractures. Tobacco consumption increased the risk for non-hip fractures.
@article{JacqminGadda1998,
abstract = {We report the results of a 5-year prospective cohort study of risk factors for fractures, including drinking fluoridated water, in a cohort of 3,216 men and women aged 65 years and older. We studied risk factors for hip fracture and fractures at other locations separately. We found a higher risk of hip fractures for subjects exposed to fluorine concentrations over 0.11 mg per liter but without a dose-effect relation (odds ratio (OR) = 3.25 for a concentration of 0.11-0.25 mg per liter; OR = 2.43 for > or = 0.25 mg per liter]. For higher thresholds (0.7 and 1 mg per liter), however, the OR was less than 1. We found no association between fluorine and non-hip fractures. Non-hip fractures were associated with polymedication rather than with specific drug use, whereas fracture was associated with polymedication and use of anxiolytic and antidepressive drugs. Subjects drinking spirits every day were more likely to have hip fractures. Tobacco consumption increased the risk for non-hip fractures.},
added-at = {2023-02-03T11:44:35.000+0100},
author = {Jacqmin-Gadda, H and Fourrier, A and Commenges, D and Dartigues, J F},
biburl = {https://www.bibsonomy.org/bibtex/2ca945062ed7c6f2e00c80f1a24e785ee/jepcastel},
interhash = {42c4757e32ee55c56d487555d7b5156b},
intrahash = {ca945062ed7c6f2e00c80f1a24e785ee},
issn = {1044-3983},
journal = {Epidemiology (Cambridge, Mass.)},
keywords = {80andover AgeFactors Aged AlcoholDrinking AlcoholDrinking:epidemiology BodyMassIndex Bone Bone:epidemiology ConfidenceIntervals Female Fluoridation Fluoridation:adverseeffects Fluoridation:statistics&numericaldata Fluorine Fluorine:adverseeffects Fractures France France:epidemiology HealthSurveys HipFractures HipFractures:epidemiology Humans LogisticModels Male MultivariateAnalysis OddsRatio Polypharmacy ProspectiveStudies PsychotropicDrugs PsychotropicDrugs:adverseeffects RiskFactors SamplingStudies SexFactors Smoking Smoking:epidemiology},
month = {7},
note = 2506,
number = 4,
pages = {417-23},
pmid = {9647906},
timestamp = {2023-02-03T11:44:35.000+0100},
title = {Risk factors for fractures in the elderly.},
url = {http://www.ncbi.nlm.nih.gov/pubmed/9647906},
volume = 9,
year = 1998
}