Covariance spectroscopy (COV), a statistical method that provides increased sensitivity, can be applied to two-dimensional high-resolution solid-state NMR experiments, such as homonuclear spin-exchange spectroscopy. We the alternative States sampling scheme to the experimental time by 50\%. By combining COV with other processing methods for non-uniform sampling (NUS), many different three-dimensional experiments can be performed with substantial increases in overall sensitivity. As an example, we show a three-dimensional homonuclear spin-exchange/separated-local-field (SLF) spectrum that enables the assignment of resonances and the measurement of structural restraints from a single experiment performed in a limited amount of time.
%0 Journal Article
%1 lin_covariance_2014
%A Lin, Eugene C
%A Opella, Stanley J
%D 2014
%J J. Magn. Reson.
%K Algorithms,Bacteriophage Isotopes,Nuclear Magnetic Pf1,Biomolecular,Capsid Processing,Signal-To-Noise Proteins,Computer-Assisted,Nitrogen Ratio Resonance,Reproducibility Results,Signal of
%P 57--60
%R 10.1016/j.jmr.2013.11.018
%T Covariance spectroscopy in high-resolution multi-dimensional solid-state \NMR\
%V 239
%X Covariance spectroscopy (COV), a statistical method that provides increased sensitivity, can be applied to two-dimensional high-resolution solid-state NMR experiments, such as homonuclear spin-exchange spectroscopy. We the alternative States sampling scheme to the experimental time by 50\%. By combining COV with other processing methods for non-uniform sampling (NUS), many different three-dimensional experiments can be performed with substantial increases in overall sensitivity. As an example, we show a three-dimensional homonuclear spin-exchange/separated-local-field (SLF) spectrum that enables the assignment of resonances and the measurement of structural restraints from a single experiment performed in a limited amount of time.
@article{lin_covariance_2014,
abstract = {Covariance spectroscopy (COV), a statistical method that provides increased sensitivity, can be applied to two-dimensional high-resolution solid-state NMR experiments, such as homonuclear spin-exchange spectroscopy. We the alternative States sampling scheme to the experimental time by 50{\%}. By combining COV with other processing methods for non-uniform sampling (NUS), many different three-dimensional experiments can be performed with substantial increases in overall sensitivity. As an example, we show a three-dimensional homonuclear spin-exchange/separated-local-field (SLF) spectrum that enables the assignment of resonances and the measurement of structural restraints from a single experiment performed in a limited amount of time.},
added-at = {2017-03-14T02:48:56.000+0100},
author = {Lin, Eugene C and Opella, Stanley J},
biburl = {https://www.bibsonomy.org/bibtex/2d1b9bc6823f9d61c2881ead35c3696e4/nmrresource},
doi = {10.1016/j.jmr.2013.11.018},
interhash = {083cc7a7d47669746b12abb7a8e2b0c5},
intrahash = {d1b9bc6823f9d61c2881ead35c3696e4},
issn = {1096-0856},
journal = {J. Magn. Reson.},
keywords = {Algorithms,Bacteriophage Isotopes,Nuclear Magnetic Pf1,Biomolecular,Capsid Processing,Signal-To-Noise Proteins,Computer-Assisted,Nitrogen Ratio Resonance,Reproducibility Results,Signal of},
month = feb,
pages = {57--60},
pmid = {24380813},
timestamp = {2017-03-14T02:49:21.000+0100},
title = {{Covariance spectroscopy in high-resolution multi-dimensional solid-state {\{}NMR{\}}}},
volume = 239,
year = 2014
}