The import of many proteins into the nucleus is mediated by the importin-α/β heterodimer. While only one importin-β gene has been found, several forms of importin-α have been described. In addition to the three human importin-αs already identified, we report here the primary structure of two new human importin-α proteins. The five known human importin-α subunits can be classified into three subfamilies that appear conserved in higher eukaryotic organisms. We show by immunoblotting that the different importin-α subfamilies are expressed in a variety of human tissues and mammalian cell lines.
Description
Cloning of two novel human importin-α subunits and analysis of the expression pattern of the importin-α protein family - ScienceDirect
%0 Journal Article
%1 khler1997cloning
%A Köhler, Matthias
%A Ansieau, Stéphane
%A Prehn, Siegfried
%A Leutz, Achim
%A Haller, Hermann
%A Hartmann, Enno
%D 1997
%J FEBS Letters
%K importin
%N 1
%P 104-108
%R https://doi.org/10.1016/S0014-5793(97)01265-9
%T Cloning of two novel human importin-α subunits and analysis of the expression pattern of the importin-α protein family
%U https://www.sciencedirect.com/science/article/pii/S0014579397012659
%V 417
%X The import of many proteins into the nucleus is mediated by the importin-α/β heterodimer. While only one importin-β gene has been found, several forms of importin-α have been described. In addition to the three human importin-αs already identified, we report here the primary structure of two new human importin-α proteins. The five known human importin-α subunits can be classified into three subfamilies that appear conserved in higher eukaryotic organisms. We show by immunoblotting that the different importin-α subfamilies are expressed in a variety of human tissues and mammalian cell lines.
@article{khler1997cloning,
abstract = {The import of many proteins into the nucleus is mediated by the importin-α/β heterodimer. While only one importin-β gene has been found, several forms of importin-α have been described. In addition to the three human importin-αs already identified, we report here the primary structure of two new human importin-α proteins. The five known human importin-α subunits can be classified into three subfamilies that appear conserved in higher eukaryotic organisms. We show by immunoblotting that the different importin-α subfamilies are expressed in a variety of human tissues and mammalian cell lines.},
added-at = {2022-05-12T14:33:07.000+0200},
author = {Köhler, Matthias and Ansieau, Stéphane and Prehn, Siegfried and Leutz, Achim and Haller, Hermann and Hartmann, Enno},
biburl = {https://www.bibsonomy.org/bibtex/2d3ba7f9706fb2a7d63ab0ccf5ccf44c5/fordham1},
description = {Cloning of two novel human importin-α subunits and analysis of the expression pattern of the importin-α protein family - ScienceDirect},
doi = {https://doi.org/10.1016/S0014-5793(97)01265-9},
interhash = {7604afba3ec35726d1842bb04f4fba46},
intrahash = {d3ba7f9706fb2a7d63ab0ccf5ccf44c5},
issn = {0014-5793},
journal = {FEBS Letters},
keywords = {importin},
number = 1,
pages = {104-108},
timestamp = {2022-05-12T14:33:07.000+0200},
title = {Cloning of two novel human importin-α subunits and analysis of the expression pattern of the importin-α protein family},
url = {https://www.sciencedirect.com/science/article/pii/S0014579397012659},
volume = 417,
year = 1997
}