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Cloning of two novel human importin-α subunits and analysis of the expression pattern of the importin-α protein family

, , , , , and . FEBS Letters, 417 (1): 104-108 (1997)
DOI: https://doi.org/10.1016/S0014-5793(97)01265-9

Abstract

The import of many proteins into the nucleus is mediated by the importin-α/β heterodimer. While only one importin-β gene has been found, several forms of importin-α have been described. In addition to the three human importin-αs already identified, we report here the primary structure of two new human importin-α proteins. The five known human importin-α subunits can be classified into three subfamilies that appear conserved in higher eukaryotic organisms. We show by immunoblotting that the different importin-α subfamilies are expressed in a variety of human tissues and mammalian cell lines.

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Cloning of two novel human importin-α subunits and analysis of the expression pattern of the importin-α protein family - ScienceDirect

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