High-throughput molecular profiling and computational biology are changing the face of virology, providing a new appreciation of the importance of the host in viral pathogenesis and offering unprecedented opportunities for better diagnostics, therapeutics and vaccines. Here, we provide a snapshot of the evolution of systems virology, from global gene expression profiling and signatures of disease outcome, to geometry-based computational methods that promise to yield novel therapeutic targets, personalized medicine and a deeper understanding of how viruses cause disease. To realize these goals, pipettes and Petri dishes need to join forces with the powers of mathematics and computational biology.
%0 Journal Article
%1 Law2013Systems
%A Law, G. Lynn
%A Korth, Marcus J.
%A Benecke, Arndt G.
%A Katze, Michael G.
%D 2013
%I Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
%J Nat Rev Micro
%K systems-biology virology
%N 7
%P 455--466
%R 10.1038/nrmicro3036
%T Systems virology: host-directed approaches to viral pathogenesis and drug targeting
%U http://dx.doi.org/10.1038/nrmicro3036
%V 11
%X High-throughput molecular profiling and computational biology are changing the face of virology, providing a new appreciation of the importance of the host in viral pathogenesis and offering unprecedented opportunities for better diagnostics, therapeutics and vaccines. Here, we provide a snapshot of the evolution of systems virology, from global gene expression profiling and signatures of disease outcome, to geometry-based computational methods that promise to yield novel therapeutic targets, personalized medicine and a deeper understanding of how viruses cause disease. To realize these goals, pipettes and Petri dishes need to join forces with the powers of mathematics and computational biology.
@article{Law2013Systems,
abstract = {High-throughput molecular profiling and computational biology are changing the face of virology, providing a new appreciation of the importance of the host in viral pathogenesis and offering unprecedented opportunities for better diagnostics, therapeutics and vaccines. Here, we provide a snapshot of the evolution of systems virology, from global gene expression profiling and signatures of disease outcome, to geometry-based computational methods that promise to yield novel therapeutic targets, personalized medicine and a deeper understanding of how viruses cause disease. To realize these goals, pipettes and Petri dishes need to join forces with the powers of mathematics and computational biology.},
added-at = {2018-12-02T16:09:07.000+0100},
author = {Law, G. Lynn and Korth, Marcus J. and Benecke, Arndt G. and Katze, Michael G.},
biburl = {https://www.bibsonomy.org/bibtex/2dd4bcbc0c909dc94472f19196c04676f/karthikraman},
citeulike-article-id = {12416134},
citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrmicro3036},
citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrmicro3036},
citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/23728212},
citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=23728212},
day = 3,
doi = {10.1038/nrmicro3036},
interhash = {4af886b13f3a686b31c76cf9c76938f9},
intrahash = {dd4bcbc0c909dc94472f19196c04676f},
issn = {1740-1534},
journal = {Nat Rev Micro},
keywords = {systems-biology virology},
month = jul,
number = 7,
pages = {455--466},
pmid = {23728212},
posted-at = {2013-06-14 11:58:25},
priority = {2},
publisher = {Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.},
timestamp = {2018-12-02T16:09:07.000+0100},
title = {Systems virology: host-directed approaches to viral pathogenesis and drug targeting},
url = {http://dx.doi.org/10.1038/nrmicro3036},
volume = 11,
year = 2013
}