%0 Journal Article %1 Ellenberg1988 %A Ellenberg, J. H. %A Nelson, K. B. %D 1988 %J J Pediatr %K Apgar Score; Birth Weight; Cerebral Palsy; Humans; Infant, Newborn; Newborn, Disease; Prognosis; Risk Factors; Seizures; s %N 3 %P 546--552 %T Cluster of perinatal events identifying infants at high risk for death or disability. %V 113 %X To determine the prognostic import of neonatal seizures according to the presence or absence of certain other postnatal characteristics, we studied a population of 39,000 infants with birth weight greater than 2500 gm. Children with clinically recognized neonatal seizures and 5-minute Apgar scores less than or equal to 5 and who had at least one of five signs compatible with neonatal encephalopathy had a risk for first-year death of 33\%. Survivors of this cluster of events (low Apgar score-abnormal signs-seizures) had a risk for motor disability of 55\%. In contrast, survivors of neonatal seizures who did not have poor Apgar scores or other abnormal signs had a risk for motor disability of only 0.13\%. Thus, among infants with neonatal seizures the risk for cerebral palsy was 420 times greater if there had been a low 5-minute Apgar score and other neonatal signs. Low Apgar score-abnormal signs-seizures constituted a cluster of events that served to identify, within the first days of life, a tiny subgroup of term newborn infants in whom risk for chronic motor disability was 55\%, and for death or disability was 70\%.

@article{Ellenberg1988, abstract = {To determine the prognostic import of neonatal seizures according to the presence or absence of certain other postnatal characteristics, we studied a population of 39,000 infants with birth weight greater than 2500 gm. Children with clinically recognized neonatal seizures and 5-minute Apgar scores less than or equal to 5 and who had at least one of five signs compatible with neonatal encephalopathy had a risk for first-year death of 33\%. Survivors of this cluster of events (low Apgar score-abnormal signs-seizures) had a risk for motor disability of 55\%. In contrast, survivors of neonatal seizures who did not have poor Apgar scores or other abnormal signs had a risk for motor disability of only 0.13\%. Thus, among infants with neonatal seizures the risk for cerebral palsy was 420 times greater if there had been a low 5-minute Apgar score and other neonatal signs. Low Apgar score-abnormal signs-seizures constituted a cluster of events that served to identify, within the first days of life, a tiny subgroup of term newborn infants in whom risk for chronic motor disability was 55\%, and for death or disability was 70\%.}, added-at = {2014-07-19T19:24:55.000+0200}, author = {Ellenberg, J. H. and Nelson, K. B.}, biburl = {https://www.bibsonomy.org/bibtex/2f16d8933ab3ede0e71d79a201311b8ea/ar0berts}, groups = {public}, interhash = {2e46428b9578e17d6963f90db1eb1cff}, intrahash = {f16d8933ab3ede0e71d79a201311b8ea}, journal = {J Pediatr}, keywords = {Apgar Score; Birth Weight; Cerebral Palsy; Humans; Infant, Newborn; Newborn, Disease; Prognosis; Risk Factors; Seizures; s}, month = Sep, number = 3, pages = {546--552}, pmid = {3411402}, timestamp = {2014-07-19T19:24:55.000+0200}, title = {Cluster of perinatal events identifying infants at high risk for death or disability.}, username = {ar0berts}, volume = 113, year = 1988 }