In this paper, we formulate a model for human ventricular cells that
is efficient enough for whole organ arrhythmia simulations yet detailed
enough to capture the effects of cell level processes such as current
blocks and channelopathies. The model is obtained from our detailed
human ventricular cell model by using mathematical techniques to
reduce the number of variables from 19 to nine. We carefully compare
our full and reduced model at the single cell, cable and 2D tissue
level and show that the reduced model has a very similar behaviour.
Importantly, the new model correctly produces the effects of current
blocks and channelopathies on AP and spiral wave behaviour, processes
at the core of current day arrhythmia research. The new model is
well over four times more efficient than the full model. We conclude
that the new model can be used for efficient simulations of the effects
of current changes on arrhythmias in the human heart.
%0 Journal Article
%1 Tuss_2006_6141
%A Tusscher, K H W J Ten
%A Panfilov, A V
%D 2006
%J Physics in Medicine and Biology
%K imported
%N 23
%P 6141-6156
%T Cell model for efficient simulation of wave propagation in human
ventricular tissue under normal and pathological conditions
%U http://stacks.iop.org/0031-9155/51/6141
%V 51
%X In this paper, we formulate a model for human ventricular cells that
is efficient enough for whole organ arrhythmia simulations yet detailed
enough to capture the effects of cell level processes such as current
blocks and channelopathies. The model is obtained from our detailed
human ventricular cell model by using mathematical techniques to
reduce the number of variables from 19 to nine. We carefully compare
our full and reduced model at the single cell, cable and 2D tissue
level and show that the reduced model has a very similar behaviour.
Importantly, the new model correctly produces the effects of current
blocks and channelopathies on AP and spiral wave behaviour, processes
at the core of current day arrhythmia research. The new model is
well over four times more efficient than the full model. We conclude
that the new model can be used for efficient simulations of the effects
of current changes on arrhythmias in the human heart.
@article{Tuss_2006_6141,
abstract = {In this paper, we formulate a model for human ventricular cells that
is efficient enough for whole organ arrhythmia simulations yet detailed
enough to capture the effects of cell level processes such as current
blocks and channelopathies. The model is obtained from our detailed
human ventricular cell model by using mathematical techniques to
reduce the number of variables from 19 to nine. We carefully compare
our full and reduced model at the single cell, cable and 2D tissue
level and show that the reduced model has a very similar behaviour.
Importantly, the new model correctly produces the effects of current
blocks and channelopathies on AP and spiral wave behaviour, processes
at the core of current day arrhythmia research. The new model is
well over four times more efficient than the full model. We conclude
that the new model can be used for efficient simulations of the effects
of current changes on arrhythmias in the human heart.},
added-at = {2009-06-03T11:20:58.000+0200},
author = {Tusscher, K H W J Ten and Panfilov, A V},
biburl = {https://www.bibsonomy.org/bibtex/2f7a55e0afa80cc09b203f0c74f6ef9bf/hake},
description = {The whole bibliography file I use.},
file = {Tuss_2006_6141.pdf:Tuss_2006_6141.pdf:PDF},
interhash = {fd7f173f2c7dca0ab6d3170a0ed2a872},
intrahash = {f7a55e0afa80cc09b203f0c74f6ef9bf},
journal = {Physics in Medicine and Biology},
keywords = {imported},
number = 23,
pages = {6141-6156},
pdf = {Tuss_2006_6141.pdf},
timestamp = {2009-06-03T11:21:34.000+0200},
title = {Cell model for efficient simulation of wave propagation in human
ventricular tissue under normal and pathological conditions},
url = {http://stacks.iop.org/0031-9155/51/6141},
volume = 51,
year = 2006
}