Classical models of genotype-to-phenotype relationships for human Mendelian disorders generally assume that a mutation causes complete loss of a gene product. A recent paper shows that an alternative, network-based approach is better suited to explain observed phenotypes.
%0 Journal Article
%1 Muers2009Human
%A Muers, Mary
%D 2009
%I Nature Publishing Group
%J Nature Reviews Genetics
%K commentary disease networks
%N 1
%P 4--5
%R 10.1038/nrg2720
%T Human disease: Edges, nodes and networks
%U http://dx.doi.org/10.1038/nrg2720
%V 11
%X Classical models of genotype-to-phenotype relationships for human Mendelian disorders generally assume that a mutation causes complete loss of a gene product. A recent paper shows that an alternative, network-based approach is better suited to explain observed phenotypes.
@article{Muers2009Human,
abstract = {Classical models of genotype-to-phenotype relationships for human Mendelian disorders generally assume that a mutation causes complete loss of a gene product. A recent paper shows that an alternative, network-based approach is better suited to explain observed phenotypes.},
added-at = {2018-12-02T16:09:07.000+0100},
author = {Muers, Mary},
biburl = {https://www.bibsonomy.org/bibtex/2fe04ad9435e350d3211c6227c1bfb06f/karthikraman},
citeulike-article-id = {6218750},
citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrg2720},
citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrg2720},
day = 24,
doi = {10.1038/nrg2720},
interhash = {307dc88979b3a2cf4c96517d8d673484},
intrahash = {fe04ad9435e350d3211c6227c1bfb06f},
issn = {1471-0056},
journal = {Nature Reviews Genetics},
keywords = {commentary disease networks},
month = nov,
number = 1,
pages = {4--5},
posted-at = {2009-11-27 08:49:36},
priority = {2},
publisher = {Nature Publishing Group},
timestamp = {2018-12-02T16:09:07.000+0100},
title = {Human disease: Edges, nodes and networks},
url = {http://dx.doi.org/10.1038/nrg2720},
volume = 11,
year = 2009
}