%0 Journal Article %1 Haven.1987 %A Haven, M. C. %A Orsulak, P. J. %A Arnold, L. L. %A Crowley, G. %D 1987 %J Clin.Chem. %K Diagnostic Humans Hyperthyroidism Hypothyroidism Immunoassay Iodine Kits Mathematics Radioisotopes Reagent Software Statistics Thyrotropin Topic as blood methods %N 7 %P 1207-1210 %T Data-reduction methods for immunoradiometric assays of thyrotropin compared %U PM:3594849 %V 33 %X In an attempt to optimize curve fitting for immunoradiometric assays, we investigated eight data-reduction methods with two commercially available assays of thyrotropin. In four of these methods linear data-reduction models are used: logit-log programs of Iso-Data, Micromedic, and Hewlitt-Packard, and probit-log of Hewlitt-Packard. The other four were nonlinear data-reduction models: Iso-Data's "French curve" (modified spline), four-parameter logistic function, and point-to-point methods, as well as a nonlinear least squares method. In using the eight data-reduction methods on data from analyses of 78 patients' samples, we found clinically relevant differences between models. In fact, differences found by changing data-reduction models were greater than the difference between the two commercial kits

@article{Haven.1987, abstract = {In an attempt to optimize curve fitting for immunoradiometric assays, we investigated eight data-reduction methods with two commercially available assays of thyrotropin. In four of these methods linear data-reduction models are used: logit-log programs of Iso-Data, Micromedic, and Hewlitt-Packard, and probit-log of Hewlitt-Packard. The other four were nonlinear data-reduction models: Iso-Data's "French curve" (modified spline), four-parameter logistic function, and point-to-point methods, as well as a nonlinear least squares method. In using the eight data-reduction methods on data from analyses of 78 patients' samples, we found clinically relevant differences between models. In fact, differences found by changing data-reduction models were greater than the difference between the two commercial kits}, added-at = {2010-02-05T11:28:39.000+0100}, author = {Haven, M. C. and Orsulak, P. J. and Arnold, L. L. and Crowley, G.}, biburl = {https://www.bibsonomy.org/bibtex/2e3c124a2cf35695901a1eb6deb2b5195/kanefendt}, interhash = {31b910fa116577b217d7b2642854fc40}, intrahash = {e3c124a2cf35695901a1eb6deb2b5195}, journal = {Clin.Chem.}, keywords = {Diagnostic Humans Hyperthyroidism Hypothyroidism Immunoassay Iodine Kits Mathematics Radioisotopes Reagent Software Statistics Thyrotropin Topic as blood methods}, number = 7, pages = {1207-1210}, timestamp = {2010-02-05T11:28:44.000+0100}, title = {Data-reduction methods for immunoradiometric assays of thyrotropin compared}, url = {PM:3594849}, volume = 33, year = 1987 }