%0 Journal Article %1 Nielsen1996 %A Nielsen, J. F. %A Sinkjaer, T. %A Jakobsen, J. %D 1996 %J Mult Scler %K Activities of Daily Living; Adult; Aged; Differential Threshold; Double-Blind Method; Electric Stimulation Therapy; Female; H-Reflex; Humans; Magnetics; Male; Middle Multiple Sclerosis, complications; Muscle Contraction; Spasticity, etiology/physiopathology/therapy; Muscles, physiopathology; Reflex, Stretch; Treatment Outcome; Volition %N 5 %P 227--232 %T Treatment of spasticity with repetitive magnetic stimulation; a double-blind placebo-controlled study. %V 2 %X The effect of repetitive magnetic stimulation on spasticity was evaluated in 38 patients with multiple sclerosis in a double-blind placebo-controlled study. One group was treated with repetitive magnetic stimulation (n = 21) and the other group with sham stimulation (n = 17). Both groups were treated twice daily for 7 consecutive days. Primary end-points of the study were changes in the patients self-score, in clinical spasticity score, and in the stretch reflex threshold. The self-score of ease of daily day activities improved by 22\% (P = 0.007) after treatment and by 29\% (P = 0.004) after sham stimulation. The clinical spasticity score improved -3.3 +/- 4.7 arbitrary unit (AU) in treated patients and 0.7 +/- 2.5 AU in sham stimulation (P = 0.003). The stretch reflex threshold increased 4.3 +/- 7.5 deg/s in treated patients and -3.8 +/- 9.7 deg/s in sham stimulation (P = 0.001). The data presented in this study supports the idea that repetitive magnetic stimulation has an antispastic effect in multiple sclerosis. Future studies should clarify the optimal treatment regimen.

@article{Nielsen1996, abstract = {The effect of repetitive magnetic stimulation on spasticity was evaluated in 38 patients with multiple sclerosis in a double-blind placebo-controlled study. One group was treated with repetitive magnetic stimulation (n = 21) and the other group with sham stimulation (n = 17). Both groups were treated twice daily for 7 consecutive days. Primary end-points of the study were changes in the patients self-score, in clinical spasticity score, and in the stretch reflex threshold. The self-score of ease of daily day activities improved by 22\% (P = 0.007) after treatment and by 29\% (P = 0.004) after sham stimulation. The clinical spasticity score improved -3.3 +/- 4.7 arbitrary unit (AU) in treated patients and 0.7 +/- 2.5 AU in sham stimulation (P = 0.003). The stretch reflex threshold increased 4.3 +/- 7.5 deg/s in treated patients and -3.8 +/- 9.7 deg/s in sham stimulation (P = 0.001). The data presented in this study supports the idea that repetitive magnetic stimulation has an antispastic effect in multiple sclerosis. Future studies should clarify the optimal treatment regimen.}, added-at = {2014-07-19T17:16:05.000+0200}, author = {Nielsen, J. F. and Sinkjaer, T. and Jakobsen, J.}, biburl = {https://www.bibsonomy.org/bibtex/2ed35fb7fb0c25edd5560b6d8a4516c10/ar0berts}, groups = {public}, institution = {Department of Neurology, Aarhus University Hospital, Denmark.}, interhash = {3558043a573f79ddeda9c8f925634d6e}, intrahash = {ed35fb7fb0c25edd5560b6d8a4516c10}, journal = {Mult Scler}, keywords = {Activities of Daily Living; Adult; Aged; Differential Threshold; Double-Blind Method; Electric Stimulation Therapy; Female; H-Reflex; Humans; Magnetics; Male; Middle Multiple Sclerosis, complications; Muscle Contraction; Spasticity, etiology/physiopathology/therapy; Muscles, physiopathology; Reflex, Stretch; Treatment Outcome; Volition}, language = {eng}, medline-pst = {ppublish}, month = Dec, number = 5, pages = {227--232}, pmid = {9050361}, timestamp = {2014-07-19T17:16:05.000+0200}, title = {Treatment of spasticity with repetitive magnetic stimulation; a double-blind placebo-controlled study.}, username = {ar0berts}, volume = 2, year = 1996 }