Article,

The Effect of Vitamin D Deficiency on The Course of Pregnancy During Premature Birth

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CENTRAL ASIAN JOURNAL OF MEDICAL AND NATURAL SCIENCE, 4 (6): 389-395 (December 2023)

Abstract

The problem of premature birth does not lose its relevance, and the frequency of this complication of pregnancy does not tend to decrease. Premature birth (PB) remains one of the urgent problems of modern obstetrics, since it determines the level of perinatal mortality and morbidity. Recently, there has been a sharp increase in interest in the "hormone D" - calcitriol and its receptors (VDR) as risk factors for the development of a number of obstetric complications. Vitamin D receptors have been found in the ovaries, uterus, placenta, and pituitary gland. According to some studies, vitamin D deficiency during pregnancy increases the risk of preterm birth. It is involved in the processes of angiogenesis, inhibition of cell proliferation, maintains genetic homeostasis and final differentiation of fetuses, affects the production of macrophages, the functioning of the pancreas, and the reninangiotensin system (1,16,32).

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