%0 Journal Article %1 Lai2003 %A Lai, Dejian %A King, Terri M %A Moyé, Lemuel A %A Wei, Qingyi %D 2003 %J Annals of epidemiology %K Adult Aged Aging BasalCell BasalCell:epidemiology BasalCell:genetics BiologicalMarkers BiologicalMarkers:analysis Carcinoma CostControl DNARepair EpidemiologicStudies Humans MiddleAged ReproducibilityofResults ResearchDesign SampleSize %N 3 %P 204-8 %T Sample size for biomarker studies: more subjects or more measurements per subject? %U http://www.ncbi.nlm.nih.gov/pubmed/12604165 %V 13 %X PURPOSE: In molecular epidemiologic studies, optimizing the use of available biological specimens while minimizing the cost is always a challenge. This is particularly true in pilot studies, which often have limited funding and involve small numbers of biological samples too small for assessment of recently developed biomarkers. METHODS: In this study we examined several statistical approaches for determining how many experimental subjects to use in a biomarker study and how many repeated measurements to make on each sample, given specific funding considerations and the correlated nature of the repeated measurements. RESULTS: A molecular epidemiology study of DNA repair and aging in basal cell carcinoma was used to illustrate the application of the statistical methods proposed. CONCLUSIONS: Our methods extend traditional designs on biomarker studies with repeated measurements to including funding constraints.

@article{Lai2003, abstract = {PURPOSE: In molecular epidemiologic studies, optimizing the use of available biological specimens while minimizing the cost is always a challenge. This is particularly true in pilot studies, which often have limited funding and involve small numbers of biological samples too small for assessment of recently developed biomarkers. METHODS: In this study we examined several statistical approaches for determining how many experimental subjects to use in a biomarker study and how many repeated measurements to make on each sample, given specific funding considerations and the correlated nature of the repeated measurements. RESULTS: A molecular epidemiology study of DNA repair and aging in basal cell carcinoma was used to illustrate the application of the statistical methods proposed. CONCLUSIONS: Our methods extend traditional designs on biomarker studies with repeated measurements to including funding constraints.}, added-at = {2023-02-03T11:44:35.000+0100}, author = {Lai, Dejian and King, Terri M and Moyé, Lemuel A and Wei, Qingyi}, biburl = {https://www.bibsonomy.org/bibtex/2b8a42ee0534fd895f8281cd5d162db07/jepcastel}, interhash = {3db38ce9f28b8135edbc2a2e938ca15b}, intrahash = {b8a42ee0534fd895f8281cd5d162db07}, issn = {1047-2797}, journal = {Annals of epidemiology}, keywords = {Adult Aged Aging BasalCell BasalCell:epidemiology BasalCell:genetics BiologicalMarkers BiologicalMarkers:analysis Carcinoma CostControl DNARepair EpidemiologicStudies Humans MiddleAged ReproducibilityofResults ResearchDesign SampleSize}, month = {3}, note = {3153<m:linebreak></m:linebreak>Sample size; Surrogate endpoints; Dades longitudinals}, number = 3, pages = {204-8}, pmid = {12604165}, timestamp = {2023-02-03T11:44:35.000+0100}, title = {Sample size for biomarker studies: more subjects or more measurements per subject?}, url = {http://www.ncbi.nlm.nih.gov/pubmed/12604165}, volume = 13, year = 2003 }