%0 Journal Article %1 Panutsopulos.2003 %A Panutsopulos, D. %A Zafiropoulos, A. %A Krambovitis, E. %A Kochiadakis, G. E. %A Igoumenidis, N. E. %A Spandidos, D. A. %D 2003 %J J.Transl.Med. %K Arteries Artery Coronary Disease Human Laboratories Lymphocytes Macrophages Monocytes Population analysis blood cells methods response %N 1 %P 6 %T Peripheral monocytes from diabetic patients with coronary artery disease display increased bFGF and VEGF mRNA expression %U PM:14585103 %V 1 %X BACKGROUND: Macrophages can produce vascular endothelial growth factor (VEGF) in response to hypoxia, transforming growth factor beta1 (TGF-beta1), angiotensin II, basic fibroblast growth factor (bFGF), and interleukin-1. These factors have been found in the serum of coronary artery disease (CAD) patients as well as in atherosclerotic lesions. The aim of the present study was to test the hypothesis that the expression of VEGF, TGF-beta1 and bFGF in peripheral monocytes and lymphocytes is related to CAD. METHODS: Human Mononuclear cells and lymphocytes from peripheral blood were isolated from 53 donors undergoing angiography. Seventeen were found to be healthy and 36 were diagnosed with CAD. The respective mRNAs were extracted and quantified. RESULTS: The statistical analysis revealed a significant increase of the basal level expression for macrophage VEGF and bFGF in the CAD SA (stable angina) patient group compared to the noCAD (control) (p = 0.041 and p = 0.022 respectively) and CAD

@article{Panutsopulos.2003, abstract = {BACKGROUND: Macrophages can produce vascular endothelial growth factor (VEGF) in response to hypoxia, transforming growth factor beta1 (TGF-beta1), angiotensin II, basic fibroblast growth factor (bFGF), and interleukin-1. These factors have been found in the serum of coronary artery disease (CAD) patients as well as in atherosclerotic lesions. The aim of the present study was to test the hypothesis that the expression of VEGF, TGF-beta1 and bFGF in peripheral monocytes and lymphocytes is related to CAD. METHODS: Human Mononuclear cells and lymphocytes from peripheral blood were isolated from 53 donors undergoing angiography. Seventeen were found to be healthy and 36 were diagnosed with CAD. The respective mRNAs were extracted and quantified. RESULTS: The statistical analysis revealed a significant increase of the basal level expression for macrophage VEGF and bFGF in the CAD SA (stable angina) patient group compared to the noCAD (control) (p = 0.041 and p = 0.022 respectively) and CAD }, added-at = {2010-02-05T11:28:39.000+0100}, author = {Panutsopulos, D. and Zafiropoulos, A. and Krambovitis, E. and Kochiadakis, G. E. and Igoumenidis, N. E. and Spandidos, D. A.}, biburl = {https://www.bibsonomy.org/bibtex/2c82a05ede0b7ec32c3dd2a31d8083673/kanefendt}, interhash = {436926ab863ad2f597df2a65977fa3c3}, intrahash = {c82a05ede0b7ec32c3dd2a31d8083673}, journal = {J.Transl.Med.}, keywords = {Arteries Artery Coronary Disease Human Laboratories Lymphocytes Macrophages Monocytes Population analysis blood cells methods response}, number = 1, pages = 6, timestamp = {2010-02-05T11:28:40.000+0100}, title = {Peripheral monocytes from diabetic patients with coronary artery disease display increased bFGF and VEGF mRNA expression}, url = {PM:14585103}, volume = 1, year = 2003 }