%0 Journal Article %1 Madsen2011Linking %A Madsen, Karina M. %A Udatha, Gupta D. %A Semba, Saori %A Otero, Jose M. %A Koetter, Peter %A Nielsen, Jens %A Ebizuka, Yutaka %A Kushiro, Tetsuo %A Panagiotou, Gianni %D 2011 %J PloS one %K metabolic-engineering yeast %N 3 %R 10.1371/journal.pone.0014763 %T Linking Genotype and Phenotype of Saccharomyces cerevisiae Strains Reveals Metabolic Engineering Targets and Leads to Triterpene Hyper-Producers. %U http://dx.doi.org/10.1371/journal.pone.0014763 %V 6 %X The six out of seven gene over-expression constructs had a considerable impact on both ergosterol and β-amyrin production. In the case of β-amyrin formation the triple over-expression construct exhibited a nearly 500\% increase over the control strain making our metabolic engineering strategy the most successful design of triterpene microbial producers.

@article{Madsen2011Linking, abstract = {The six out of seven gene over-expression constructs had a considerable impact on both ergosterol and β-amyrin production. In the case of β-amyrin formation the triple over-expression construct exhibited a nearly 500\% increase over the control strain making our metabolic engineering strategy the most successful design of triterpene microbial producers.}, added-at = {2018-12-02T16:09:07.000+0100}, author = {Madsen, Karina M. and Udatha, Gupta D. and Semba, Saori and Otero, Jose M. and Koetter, Peter and Nielsen, Jens and Ebizuka, Yutaka and Kushiro, Tetsuo and Panagiotou, Gianni}, biburl = {https://www.bibsonomy.org/bibtex/25ecbd5c5fc75797468a42807c8f3c4e0/karthikraman}, citeulike-article-id = {9228059}, citeulike-linkout-0 = {http://dx.doi.org/10.1371/journal.pone.0014763}, citeulike-linkout-1 = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060802/}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/21445244}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=21445244}, doi = {10.1371/journal.pone.0014763}, interhash = {473e51c4e91513b514682248dcfe260d}, intrahash = {5ecbd5c5fc75797468a42807c8f3c4e0}, issn = {1932-6203}, journal = {PloS one}, keywords = {metabolic-engineering yeast}, number = 3, pmcid = {PMC3060802}, pmid = {21445244}, posted-at = {2011-04-29 10:17:21}, priority = {2}, timestamp = {2018-12-02T16:09:07.000+0100}, title = {Linking Genotype and Phenotype of Saccharomyces cerevisiae Strains Reveals Metabolic Engineering Targets and Leads to Triterpene {Hyper-Producers}.}, url = {http://dx.doi.org/10.1371/journal.pone.0014763}, volume = 6, year = 2011 }