Abstract
The complex intraparticle structure typical of chromatographic column
packings has been analyzed by use of an equivalent network model which
emphasizes pore size distribution and connectivity. Special attention is
given as to the way in which diffusion and adsorption interact and
display modified peak spreading characteristics according to the
morphology of the pore space. This study reveals a very significant
increase in the column band broadening over that expected from physical
adsorption which can arise from particular distributions of pore sizes.
This has implications for designing packings which take advantage of the
separating power due to adsorption but do not compromise the resolution
of the chromatographic system.
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