%0 Journal Article %1 Frauenfelder1991ProteinEnergyLandscape %A Frauenfelder, H %A Sligar, SG %A Wolynes, PG %D 1991 %I American Association for the Advancement of Science %J Science %K biophysics energy-landscape protein protein-motions %N 5038 %P 1598--1603 %R 10.1126/science.1749933 %T The energy landscapes and motions of proteins %U http://science.sciencemag.org/content/254/5038/1598 %V 254 %X Recent experiments, advances in theory, and analogies to other complex systems such as glasses and spin glasses yield insight into protein dynamics. The basis of the understanding is the observation that the energy landscape is complex: Proteins can assume a large number of nearly isoenergetic conformations (conformational substates). The concepts that emerge from studies of the conformational substates and the motions between them permit a quantitative discussion of one simple reaction, the binding of small ligands such as carbon monoxide to myoglobin.

@article{Frauenfelder1991ProteinEnergyLandscape, abstract = {Recent experiments, advances in theory, and analogies to other complex systems such as glasses and spin glasses yield insight into protein dynamics. The basis of the understanding is the observation that the energy landscape is complex: Proteins can assume a large number of nearly isoenergetic conformations (conformational substates). The concepts that emerge from studies of the conformational substates and the motions between them permit a quantitative discussion of one simple reaction, the binding of small ligands such as carbon monoxide to myoglobin.}, added-at = {2018-03-12T19:14:11.000+0100}, author = {Frauenfelder, H and Sligar, SG and Wolynes, PG}, biburl = {https://www.bibsonomy.org/bibtex/2c5a9ebd21f9a4e613ae7eb97887c94b5/salotz}, description = {The energy landscapes and motions of proteins | Science}, doi = {10.1126/science.1749933}, eprint = {http://science.sciencemag.org/content/254/5038/1598.full.pdf}, interhash = {50e082365901cf3fef8fe302015a5a67}, intrahash = {c5a9ebd21f9a4e613ae7eb97887c94b5}, issn = {0036-8075}, journal = {Science}, keywords = {biophysics energy-landscape protein protein-motions}, number = 5038, pages = {1598--1603}, publisher = {American Association for the Advancement of Science}, timestamp = {2018-03-12T21:08:50.000+0100}, title = {The energy landscapes and motions of proteins}, url = {http://science.sciencemag.org/content/254/5038/1598}, volume = 254, year = 1991 }