%0 Journal Article %1 McKeague2016Opportunities %A McKeague, Maureen %A Wong, Remus S. %A Smolke, Christina D. %D 2016 %J Nucleic acids research %K expression rna synthetic-biology %T Opportunities in the design and application of RNA for gene expression control. %U http://view.ncbi.nlm.nih.gov/pubmed/26969733 %X The past decade of synthetic biology research has witnessed numerous advances in the development of tools and frameworks for the design and characterization of biological systems. Researchers have focused on the use of RNA for gene expression control due to its versatility in sensing molecular ligands and the relative ease by which RNA can be modeled and designed compared to proteins. We review the recent progress in the field with respect to RNA-based genetic devices that are controlled through small molecule and protein interactions. We discuss new approaches for generating and characterizing these devices and their underlying components. We also highlight immediate challenges, future directions and recent applications of synthetic RNA devices in engineered biological systems. \copyright The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

@article{McKeague2016Opportunities, abstract = {The past decade of synthetic biology research has witnessed numerous advances in the development of tools and frameworks for the design and characterization of biological systems. Researchers have focused on the use of {RNA} for gene expression control due to its versatility in sensing molecular ligands and the relative ease by which {RNA} can be modeled and designed compared to proteins. We review the recent progress in the field with respect to {RNA}-based genetic devices that are controlled through small molecule and protein interactions. We discuss new approaches for generating and characterizing these devices and their underlying components. We also highlight immediate challenges, future directions and recent applications of synthetic {RNA} devices in engineered biological systems. {\copyright} The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.}, added-at = {2018-12-02T16:09:07.000+0100}, author = {McKeague, Maureen and Wong, Remus S. and Smolke, Christina D.}, biburl = {https://www.bibsonomy.org/bibtex/28de9652950fc46ad4a3053308a9bcca0/karthikraman}, citeulike-article-id = {13978985}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/26969733}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=26969733}, day = 11, interhash = {59a138d7385b22be6c665637d29df647}, intrahash = {8de9652950fc46ad4a3053308a9bcca0}, issn = {1362-4962}, journal = {Nucleic acids research}, keywords = {expression rna synthetic-biology}, month = mar, pmid = {26969733}, posted-at = {2016-03-24 09:17:15}, priority = {2}, timestamp = {2018-12-02T16:09:07.000+0100}, title = {Opportunities in the design and application of {RNA} for gene expression control.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/26969733}, year = 2016 }