%0 Journal Article %1 pybus2015virus %A Pybus, Oliver G. %A Tatem, Andrew J. %A Lemey, Philippe %D 2015 %I The Royal Society %J Proceedings of the Royal Society of London B: Biological Sciences %K data_sharing evolution genetic_data geospatial_data outbreak %N 1821 %R 10.1098/rspb.2014.2878 %T Virus evolution and transmission in an ever more connected world %U http://rspb.royalsocietypublishing.org/content/282/1821/20142878 %V 282 %X The frequency and global impact of infectious disease outbreaks, particularly those caused by emerging viruses, demonstrate the need for a better understanding of how spatial ecology and pathogen evolution jointly shape epidemic dynamics. Advances in computational techniques and the increasing availability of genetic and geospatial data are helping to address this problem, particularly when both information sources are combined. Here, we review research at the intersection of evolutionary biology, human geography and epidemiology that is working towards an integrated view of spatial incidence, host mobility and viral genetic diversity. We first discuss how empirical studies have combined viral spatial and genetic data, focusing particularly on the contribution of evolutionary analyses to epidemiology and disease control. Second, we explore the interplay between virus evolution and global dispersal in more depth for two pathogens: human influenza A virus and chikungunya virus. We discuss the opportunities for future research arising from new analyses of human transportation and trade networks, as well as the associated challenges in accessing and sharing relevant spatial and genetic data.

@article{pybus2015virus, abstract = {The frequency and global impact of infectious disease outbreaks, particularly those caused by emerging viruses, demonstrate the need for a better understanding of how spatial ecology and pathogen evolution jointly shape epidemic dynamics. Advances in computational techniques and the increasing availability of genetic and geospatial data are helping to address this problem, particularly when both information sources are combined. Here, we review research at the intersection of evolutionary biology, human geography and epidemiology that is working towards an integrated view of spatial incidence, host mobility and viral genetic diversity. We first discuss how empirical studies have combined viral spatial and genetic data, focusing particularly on the contribution of evolutionary analyses to epidemiology and disease control. Second, we explore the interplay between virus evolution and global dispersal in more depth for two pathogens: human influenza A virus and chikungunya virus. We discuss the opportunities for future research arising from new analyses of human transportation and trade networks, as well as the associated challenges in accessing and sharing relevant spatial and genetic data.}, added-at = {2016-06-07T05:52:33.000+0200}, author = {Pybus, Oliver G. and Tatem, Andrew J. and Lemey, Philippe}, biburl = {https://www.bibsonomy.org/bibtex/230ad915505a1c383c36598ec371b2a83/isaric1}, doi = {10.1098/rspb.2014.2878}, eprint = {http://rspb.royalsocietypublishing.org/content/282/1821/20142878.full.pdf}, interhash = {63df106354591cabc670245cb31f056d}, intrahash = {30ad915505a1c383c36598ec371b2a83}, issn = {0962-8452}, journal = {Proceedings of the Royal Society of London B: Biological Sciences}, keywords = {data_sharing evolution genetic_data geospatial_data outbreak}, number = 1821, publisher = {The Royal Society}, timestamp = {2016-06-08T03:25:37.000+0200}, title = {Virus evolution and transmission in an ever more connected world}, url = {http://rspb.royalsocietypublishing.org/content/282/1821/20142878}, volume = 282, year = 2015 }