Abstract
Analysis of genomic segments shared identical-by-descent (IBD) between
individuals is fundamental to many genetic applications, but IBD detection
accuracy in non-simulated data is largely unknown. Using 25,432 genotyped
European individuals, and exploiting known familial relationships in 2,952
father-mother-child trios contained therein, we identify a false positive rate
over 67% for short (2-4 centiMorgan) segments. We introduce a novel,
computationally-efficient, haplotype-based metric that enables accurate IBD
detection on population-scale datasets.
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