%0 Journal Article %1 Gold_2005_122 %A Goldhaber, Joshua I %A Henderson, Scott A %A Reuter, Hannes %A Pott, Christian %A Philipson, Kenneth D %D 2005 %J Ann. N. Y. Acad. Sci. %K 16093490 Action Animals, Ca, Calcium, Cardiac, Cardiomegaly, Contraction, Disease, Electrophysiology, Energy Exchanger, Extramural, Genetic Gov't, Homozygote, Injury, Isoproterenol, Knockout, Metabolism, Mice, Myocardial Myocardium, Myocytes, N.I.H., Non-U.S. P.H.S., Phenotype, Potentials, Predisposition Reperfusion Research Sarcolemma, Sodium, Sodium-Calcium Support, Transgenic, U.S. lcium, to %P 122--126 %R 10.1196/annals.1341.011 %T Effects of Na$^+$-Ca$^2+$ exchange expression on excitation-contraction coupling in genetically modified mice. %U http://dx.doi.org/10.1196/annals.1341.011 %V 1047 %X We have created genetically altered mice to investigate how expression of the Na$^+$-Ca$^2+$ exchange protein alters excitation-contraction (E-C) coupling. Whereas low levels of exchanger overexpression have minimal effects on E-C coupling properties, high levels of overexpression in homozygous animals results in susceptibility to hypertrophy and heart failure, along with a significant reduction in E-C coupling gain. While global knockout of the exchanger in mice is embryonic-lethal, conditional knockout mice live to adulthood. Cardiac function is surprisingly normal in seven-week-old mice, but E-C coupling gain is apparently increased. Thus, genetic modification of exchanger expression has a major influence on E-C coupling.

@article{Gold_2005_122, abstract = {We have created genetically altered mice to investigate how expression of the {N}a$^{+}$-{C}a$^{2+}$ exchange protein alters excitation-contraction (E-C) coupling. Whereas low levels of exchanger overexpression have minimal effects on E-C coupling properties, high levels of overexpression in homozygous animals results in susceptibility to hypertrophy and heart failure, along with a significant reduction in E-C coupling gain. While global knockout of the exchanger in mice is embryonic-lethal, conditional knockout mice live to adulthood. Cardiac function is surprisingly normal in seven-week-old mice, but E-C coupling gain is apparently increased. Thus, genetic modification of exchanger expression has a major influence on E-C coupling.}, added-at = {2009-06-03T11:20:58.000+0200}, author = {Goldhaber, Joshua I and Henderson, Scott A and Reuter, Hannes and Pott, Christian and Philipson, Kenneth D}, biburl = {https://www.bibsonomy.org/bibtex/2b7784291ca7dda278540a408b2ab45c1/hake}, description = {The whole bibliography file I use.}, doi = {10.1196/annals.1341.011}, file = {Gold_2005_122.pdf:Gold_2005_122.pdf:PDF}, interhash = {748d4e150018adfa049da2fc84c25e3e}, intrahash = {b7784291ca7dda278540a408b2ab45c1}, journal = {Ann. N. Y. Acad. Sci.}, keywords = {16093490 Action Animals, Ca, Calcium, Cardiac, Cardiomegaly, Contraction, Disease, Electrophysiology, Energy Exchanger, Extramural, Genetic Gov't, Homozygote, Injury, Isoproterenol, Knockout, Metabolism, Mice, Myocardial Myocardium, Myocytes, N.I.H., Non-U.S. P.H.S., Phenotype, Potentials, Predisposition Reperfusion Research Sarcolemma, Sodium, Sodium-Calcium Support, Transgenic, U.S. lcium, to}, month = Jun, pages = {122--126}, pii = {1047/1/122}, pmid = {16093490}, timestamp = {2009-06-03T11:21:12.000+0200}, title = {Effects of {N}a$^{+}$-{C}a$^{2+}$ exchange expression on excitation-contraction coupling in genetically modified mice.}, url = {http://dx.doi.org/10.1196/annals.1341.011}, volume = 1047, year = 2005 }