%0 Journal Article %1 Pocock2015b %A Pocock, Stuart J %A McMurray, John J V %A Collier, Tim J %D 2015 %J Journal of the American College of Cardiology %K Cardiology Cardiology:methods ClinicalTrialsasTopic ClinicalTrialsasTopic:methods ClinicalTrialsasTopic:standards ClinicalTrialsasTopic:statistics&numericald DataInterpretation Humans PatientCarePlanning PatientCarePlanning:organization&administrati PatientSelection ResearchDesign Statistical %N 23 %P 2648-62 %R 10.1016/j.jacc.2015.10.023 %T Statistical Controversies in Reporting of Clinical Trials: Part 2 of a 4-Part Series on Statistics for Clinical Trials. %U http://www.ncbi.nlm.nih.gov/pubmed/26670066 %V 66 %X This paper tackles several statistical controversies that are commonly faced when reporting a major clinical trial. Topics covered include: multiplicity of data, interpreting secondary endpoints and composite endpoints, the value of covariate adjustment, the traumas of subgroup analysis, assessing individual benefits and risks, alternatives to analysis by intention to treat, interpreting surprise findings (good and bad), and the overall quality of clinical trial reports. All is put in the context of topical cardiology trial examples and is geared to help trialists steer a wise course in their statistical reporting, thereby giving readers a balanced account of trial findings.

@article{Pocock2015b, abstract = {This paper tackles several statistical controversies that are commonly faced when reporting a major clinical trial. Topics covered include: multiplicity of data, interpreting secondary endpoints and composite endpoints, the value of covariate adjustment, the traumas of subgroup analysis, assessing individual benefits and risks, alternatives to analysis by intention to treat, interpreting surprise findings (good and bad), and the overall quality of clinical trial reports. All is put in the context of topical cardiology trial examples and is geared to help trialists steer a wise course in their statistical reporting, thereby giving readers a balanced account of trial findings.}, added-at = {2023-02-03T11:44:35.000+0100}, author = {Pocock, Stuart J and McMurray, John J V and Collier, Tim J}, biburl = {https://www.bibsonomy.org/bibtex/23ad4e4c6398c7a3c86259f0d88c248c6/jepcastel}, doi = {10.1016/j.jacc.2015.10.023}, interhash = {81fae6a86abc8fa7eec660324b863e29}, intrahash = {3ad4e4c6398c7a3c86259f0d88c248c6}, issn = {1558-3597}, journal = {Journal of the American College of Cardiology}, keywords = {Cardiology Cardiology:methods ClinicalTrialsasTopic ClinicalTrialsasTopic:methods ClinicalTrialsasTopic:standards ClinicalTrialsasTopic:statistics&numericald DataInterpretation Humans PatientCarePlanning PatientCarePlanning:organization&administrati PatientSelection ResearchDesign Statistical}, month = {12}, note = {Disseny; RCT; CV; Introductori; Comparacions múltiples; Composite endpoints; Intention to treat; Anàlisi de subgrups}, number = 23, pages = {2648-62}, pmid = {26670066}, timestamp = {2023-02-03T11:44:35.000+0100}, title = {Statistical Controversies in Reporting of Clinical Trials: Part 2 of a 4-Part Series on Statistics for Clinical Trials.}, url = {http://www.ncbi.nlm.nih.gov/pubmed/26670066}, volume = 66, year = 2015 }