Abstract
Despite recent advances in preventing sudden cardiac death (SCD) due
to cardiac arrhythmia, its incidence in the population at large has
remained unacceptably high. Better understanding of the interaction
among various functional, structural, and genetic factors underlying
the susceptibility to, and initiation of, fatal arrhythmias is a
major goal and will provide new tools for the prediction, prevention,
and therapy of SCD. Here, we review the role of aberrant intracellular
Ca handling, ionic imbalances associated with acute myocardial ischemia,
neurohumoral changes, and genetic predisposition in the pathogenesis
of SCD due to cardiac arrhythmia. Therapeutic measures to prevent
SCD are also discussed.
- 16138184
- action
- arrhythmia,
- calcium,
- cardiac,
- channels,
- death,
- disease,
- electrocardiography,
- extramural,
- genetic
- gov't,
- humans,
- ion
- ischemia,
- messenger
- myocardial
- myocardium,
- n.i.h.,
- non-u.s.
- p.h.s.,
- potentials,
- predisposition
- renin-angiotensin
- research
- second
- sudden,
- support,
- system,
- systems,
- to
- u.s.
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