%0 Journal Article %1 MacDonald1997 %A MacDonald, T M %A Morant, S V %A Robinson, G C %A Shield, M J %A McGilchrist, M M %A Murray, F E %A McDevitt, D G %D 1997 %J BMJ (Clinical research ed.) %K 80andover AgeFactors Aged Anti-InflammatoryAgents CohortStudies Dose-ResponseRelationship Drug Female GastrointestinalDiseases GastrointestinalDiseases:chemicallyinduced Humans Male MiddleAged Non-Steroidal Non-Steroidal:adverseeffects PepticUlcer PepticUlcer:drugtherapy ProspectiveStudies RiskFactors TimeFactors WoundHealing %N 7119 %P 1333-7 %T Association of upper gastrointestinal toxicity of non-steroidal anti-inflammatory drugs with continued exposure: cohort study. %U http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9402773 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2127829&tool=pmcentrez&rendertype=abstract %V 315 %X OBJECTIVES: To determine the profile of risk of upper gastrointestinal toxicity during continuous treatment with, and after cessation of, non-steroidal anti-inflammatory drugs. DESIGN: Cohort study with a prospectively constructed, population based, record linkage database containing details of exposure to all community dispensed non-steroidal anti-inflammatory drugs and also all admissions to hospital for upper gastrointestinal diagnoses. SETTING: The population of Tayside, Scotland. SUBJECTS: 52,293 subjects aged 50 and over who received one or more non-steroidal anti-inflammatory between 1 January 1989 and 31 December 1991 and 73,792 subjects who did not receive one during the same period (controls). MAIN OUTCOME MEASURES: Admission to hospital for upper gastrointestinal bleeding and perforation, and admission for other upper gastrointestinal diagnoses. RESULTS: About 2% of the non-steroidal anti-inflammatory cohort were admitted with an upper gastrointestinal event during the study period compared with 1.4% of controls. The risk of admission for upper gastrointestinal haemorrhage and perforation was constant during continuous non-steroidal anti-inflammatory exposure and carried over after the end of exposure. The results were similar for admissions for all upper gastrointestinal events. CONCLUSION: This study provides evidence that non-steroidal anti-inflammatory toxicity persists with continuous exposure. There seems to be carryover toxicity after the end of prescribing. These findings have implications for the management of patients requiring non-steroidal anti-inflammatory drugs.

@article{MacDonald1997, abstract = {OBJECTIVES: To determine the profile of risk of upper gastrointestinal toxicity during continuous treatment with, and after cessation of, non-steroidal anti-inflammatory drugs. DESIGN: Cohort study with a prospectively constructed, population based, record linkage database containing details of exposure to all community dispensed non-steroidal anti-inflammatory drugs and also all admissions to hospital for upper gastrointestinal diagnoses. SETTING: The population of Tayside, Scotland. SUBJECTS: 52,293 subjects aged 50 and over who received one or more non-steroidal anti-inflammatory between 1 January 1989 and 31 December 1991 and 73,792 subjects who did not receive one during the same period (controls). MAIN OUTCOME MEASURES: Admission to hospital for upper gastrointestinal bleeding and perforation, and admission for other upper gastrointestinal diagnoses. RESULTS: About 2% of the non-steroidal anti-inflammatory cohort were admitted with an upper gastrointestinal event during the study period compared with 1.4% of controls. The risk of admission for upper gastrointestinal haemorrhage and perforation was constant during continuous non-steroidal anti-inflammatory exposure and carried over after the end of exposure. The results were similar for admissions for all upper gastrointestinal events. CONCLUSION: This study provides evidence that non-steroidal anti-inflammatory toxicity persists with continuous exposure. There seems to be carryover toxicity after the end of prescribing. These findings have implications for the management of patients requiring non-steroidal anti-inflammatory drugs.}, added-at = {2023-02-03T11:44:35.000+0100}, author = {MacDonald, T M and Morant, S V and Robinson, G C and Shield, M J and McGilchrist, M M and Murray, F E and McDevitt, D G}, biburl = {https://www.bibsonomy.org/bibtex/2e558cd2e34c1bea9e9b438fbab9ca10f/jepcastel}, city = {Department of Clinical Pharmacology, University of Dundee, Ninewells Hospital and Medical School.}, interhash = {aed08eda74aab1f2908ba372f67b35af}, intrahash = {e558cd2e34c1bea9e9b438fbab9ca10f}, issn = {0959-8138}, journal = {BMJ (Clinical research ed.)}, keywords = {80andover AgeFactors Aged Anti-InflammatoryAgents CohortStudies Dose-ResponseRelationship Drug Female GastrointestinalDiseases GastrointestinalDiseases:chemicallyinduced Humans Male MiddleAged Non-Steroidal Non-Steroidal:adverseeffects PepticUlcer PepticUlcer:drugtherapy ProspectiveStudies RiskFactors TimeFactors WoundHealing}, month = {11}, note = {9402773; 0959-8138 Journal Article; ID: 9;<br/><br/>Depleció de susceptibles; RISC-32}, number = 7119, pages = {1333-7}, pmid = {9402773}, timestamp = {2023-02-03T11:44:35.000+0100}, title = {Association of upper gastrointestinal toxicity of non-steroidal anti-inflammatory drugs with continued exposure: cohort study.}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9402773 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2127829&tool=pmcentrez&rendertype=abstract}, volume = 315, year = 1997 }