%0 Journal Article %1 Vohr2003a %A Vohr, Betty R %A Allan, Walter C %A Westerveld, Michael %A Schneider, Karen C %A Katz, Karol H %A Makuch, Robert W %A Ment, Laura R %D 2003 %J Pediatrics %K Cerebral Hemorrhage; Palsy; Ventricles; Child; Cohort Studies; Developmental Disabilities; Female; Hearing Loss; Humans; Indomethacin; Infant; Infant, Newborn; Very Low Birth Weight; Intelligence Tests; Leukomalacia, Periventricular; Male; Needs Assessment; Prospective Regression Analysis %N 4 Pt 1 %P e340--e346 %T School-age outcomes of very low birth weight infants in the indomethacin intraventricular hemorrhage prevention trial. %V 111 %X OBJECTIVE: The cohort consisted of 328 very low birth weight infants (600-1250 g birth weight) who were enrolled in the low-dose prophylactic indomethacin prevention trial and were intraventricular hemorrhage (IVH) negative at 6 postnatal hours. The objective was to determine the effects of both IVH and indomethacin on cognitive, language, and achievement performance at 8 years of age. METHODS: The cohort was divided into 4 subgroups for analysis: indomethacin plus IVH, indomethacin no IVH, saline plus IVH, and saline with no IVH. The children were evaluated prospectively at 8 years of age with a neurologic assessment, history of school performance, and a battery of cognitive, academic, behavioral, and functional assessments. RESULTS: Children in both IVH groups had more cerebral palsy; more hearing impairment; lower daily living skills scores; lower IQ, vocabulary, and reading and mathematics achievement test scores; and greater educational resource needs. With logistic regression analyses grade 3 to 4 IVH, periventricular leukomalacia and/or ventriculomegaly, male gender, maternal education, and language spoken in the home contributed to outcomes. No effects of indomethacin or gestational age were identified. CONCLUSIONS: Although biological factors including IVH, ventriculomegaly, and periventricular leukomalacia contribute significantly to school age outcomes among very low birth weight survivors at 8 years of age, social and environmental factors including maternal level of education and primary language spoken in the home are also important contributors to outcome.

@article{Vohr2003a, abstract = {OBJECTIVE: The cohort consisted of 328 very low birth weight infants (600-1250 g birth weight) who were enrolled in the low-dose prophylactic indomethacin prevention trial and were intraventricular hemorrhage (IVH) negative at 6 postnatal hours. The objective was to determine the effects of both IVH and indomethacin on cognitive, language, and achievement performance at 8 years of age. METHODS: The cohort was divided into 4 subgroups for analysis: indomethacin plus IVH, indomethacin no IVH, saline plus IVH, and saline with no IVH. The children were evaluated prospectively at 8 years of age with a neurologic assessment, history of school performance, and a battery of cognitive, academic, behavioral, and functional assessments. RESULTS: Children in both IVH groups had more cerebral palsy; more hearing impairment; lower daily living skills scores; lower IQ, vocabulary, and reading and mathematics achievement test scores; and greater educational resource needs. With logistic regression analyses grade 3 to 4 IVH, periventricular leukomalacia and/or ventriculomegaly, male gender, maternal education, and language spoken in the home contributed to outcomes. No effects of indomethacin or gestational age were identified. CONCLUSIONS: Although biological factors including IVH, ventriculomegaly, and periventricular leukomalacia contribute significantly to school age outcomes among very low birth weight survivors at 8 years of age, social and environmental factors including maternal level of education and primary language spoken in the home are also important contributors to outcome.}, added-at = {2014-07-19T21:53:35.000+0200}, author = {Vohr, Betty R and Allan, Walter C and Westerveld, Michael and Schneider, Karen C and Katz, Karol H and Makuch, Robert W and Ment, Laura R}, biburl = {https://www.bibsonomy.org/bibtex/276669e1d61c33a942a3380f3f80beb57/ar0berts}, groups = {public}, interhash = {b9da7d3c6d1308cc22bebb29cc516a65}, intrahash = {76669e1d61c33a942a3380f3f80beb57}, journal = {Pediatrics}, keywords = {Cerebral Hemorrhage; Palsy; Ventricles; Child; Cohort Studies; Developmental Disabilities; Female; Hearing Loss; Humans; Indomethacin; Infant; Infant, Newborn; Very Low Birth Weight; Intelligence Tests; Leukomalacia, Periventricular; Male; Needs Assessment; Prospective Regression Analysis}, month = Apr, number = {4 Pt 1}, pages = {e340--e346}, pmid = {12671149}, timestamp = {2014-07-19T21:53:35.000+0200}, title = {School-age outcomes of very low birth weight infants in the indomethacin intraventricular hemorrhage prevention trial.}, username = {ar0berts}, volume = 111, year = 2003 }