Аннотация
The title compound (1, trivial name: 9 (or 3)-nitrocytisine) crystallizes with two independent molecules in the asymmetric unit. In its structure two rings form a bispidine framework that is fused to a 3-nitro-2-pyridone group. The half-normal probability plot reveals that the two molecules do not show any significant geometrical differences, except in conformations of the nitro-group, which is involved in intermolecular interactions. The crystal packing structure of the title compound is described in terms of three-dimensional supramolecular arrays built up from chains of N-H center dot center dot center dot O (nitro-group), hydrogen bonds and weak intermolecular C-H center dot center dot center dot O=C interactions, with graph-set descriptors C-2(2)(6) and C-2(2)(10) motifs, which together result in R-4(4)(26) rings motifs. These chains are additionally stabilized by intermolecular NO2...pi interactions.
- acetylcholine-receptors,
- agonists,
- alpha-4-beta-2,
- crystal
- cytisine
- cytisinoid,
- derivatives,
- design
- diffraction,
- dqcauchile
- halogenated
- hydrogen-bond,
- in-vivo,
- nicotinic
- patterns,
- smoking-cessation,
- structure,
- therapeutic-efficacy,
- x-ray
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