%0 Journal Article %1 madhi_long-term_2007 %A Madhi, Shabir A %A Adrian, Peter %A Kuwanda, Locadiah %A Cutland, Clare %A Albrich, Werner C %A Klugman, Keith P %D 2007 %J The Journal of Infectious Diseases %K Child, Conjugate Factors, Female, Haemophilus Humans, Infections, Male, Nasopharynx, Opportunistic Pneumococcal Preschool, Prevalence, Seronegativity, Staphylococcal Staphylococcus Streptococcus Time Vaccines, aureus, influenzae, pneumoniae, {AIDS-Related} {HIV} %N 11 %P 1662--6 %R 10.1086/522164 %T Long-term effect of pneumococcal conjugate vaccine on nasopharyngeal colonization by Streptococcus pneumoniae--and associated interactions with Staphylococcus aureus and Haemophilus influenzae colonization--in HIV-Infected and HIV-uninfected children %U http://www.ncbi.nlm.nih.gov/pubmed/18008250 %V 196 %X After a primary series of 3 doses, it was found that a 9-valent pneumococcal conjugate vaccine no longer reduces nasopharyngeal colonization by vaccine serotypes in children 5.3 years of age. In addition, human immunodeficiency virus (HIV)-infected children (n=81) had a higher prevalence of colonization by Streptococcus pneumoniae and Haemophilus influenzae (71.6\% and 74.1\%, respectively) than did HIV-uninfected children (n=271; 50.9\% and 52.0\%, respectively), suggesting that increased colonization may contribute to the greater burden of pneumococcal disease in HIV-infected children. Inverse associations between colonization by S. pneumoniae and colonization by Staphylococcus aureus and between colonization by S. aureus and colonization by H. influenzae were observed only in HIV-uninfected children, possibly as a result of suboptimal adaptive immunity after previous colonization in HIV-infected children.

@article{madhi_long-term_2007, abstract = {After a primary series of 3 doses, it was found that a 9-valent pneumococcal conjugate vaccine no longer reduces nasopharyngeal colonization by vaccine serotypes in children 5.3 years of age. In addition, human immunodeficiency virus {(HIV)-infected} children (n=81) had a higher prevalence of colonization by Streptococcus pneumoniae and Haemophilus influenzae (71.6\% and 74.1\%, respectively) than did {HIV-uninfected} children (n=271; 50.9\% and 52.0\%, respectively), suggesting that increased colonization may contribute to the greater burden of pneumococcal disease in {HIV-infected} children. Inverse associations between colonization by S. pneumoniae and colonization by Staphylococcus aureus and between colonization by S. aureus and colonization by H. influenzae were observed only in {HIV-uninfected} children, possibly as a result of suboptimal adaptive immunity after previous colonization in {HIV-infected} children.}, added-at = {2011-03-11T10:05:34.000+0100}, author = {Madhi, Shabir A and Adrian, Peter and Kuwanda, Locadiah and Cutland, Clare and Albrich, Werner C and Klugman, Keith P}, biburl = {https://www.bibsonomy.org/bibtex/2151c65b94490fd32a1bc90c58f8e4927/jelias}, doi = {10.1086/522164}, interhash = {c62cde2bd19eef48e659f8eb87b67776}, intrahash = {151c65b94490fd32a1bc90c58f8e4927}, issn = {0022-1899}, journal = {The Journal of Infectious Diseases}, keywords = {Child, Conjugate Factors, Female, Haemophilus Humans, Infections, Male, Nasopharynx, Opportunistic Pneumococcal Preschool, Prevalence, Seronegativity, Staphylococcal Staphylococcus Streptococcus Time Vaccines, aureus, influenzae, pneumoniae, {AIDS-Related} {HIV}}, month = dec, note = {{PMID:} 18008250}, number = 11, pages = {1662--6}, timestamp = {2011-03-11T10:05:54.000+0100}, title = {Long-term effect of pneumococcal conjugate vaccine on nasopharyngeal colonization by Streptococcus pneumoniae--and associated interactions with Staphylococcus aureus and Haemophilus influenzae colonization--in {HIV-Infected} and {HIV-uninfected} children}, url = {http://www.ncbi.nlm.nih.gov/pubmed/18008250}, volume = 196, year = 2007 }