%0 Journal Article %1 pickrell2012inference %A Pickrell, Joseph K. %A Pritchard, Jonathan K. %D 2012 %I Public Library of Science %J PLoS Genet %K Wishart_distribution admixture demographic_inference human_genome methods population_genomics %N 11 %P e1002967 %R 10.1371/journal.pgen.1002967 %T Inference of Population Splits and Mixtures from Genome-Wide Allele Frequency Data %U http://dx.doi.org/10.1371%2Fjournal.pgen.1002967 %V 8 %X With modern genotyping technology, it is now possible to obtain large amounts of genetic data from many populations in a species. An important question that can be addressed with these data is: what is the history of these populations? There is a long history in population genetics of inferring the relationships among populations as a bifurcating tree, analogous to phylogenetic trees for representing the evolution of species. However, it has long been recognized that, since populations from the same species exchange genes, simple bifurcating trees may be an incorrect representation of population histories. We have developed a method to address this issue, using a model which allows for both population splits and gene flow. In application to humans, we show that we are able to identify a number of both previously known and unknown episodes of gene flow in history, including gene flow into Cambodia of a population only distantly related to modern East Asia. In application to dogs, we show that the boxer and basenji breeds have a considerable component of ancestry from grey wolves subsequent to domestication.

@article{pickrell2012inference, abstract = {With modern genotyping technology, it is now possible to obtain large amounts of genetic data from many populations in a species. An important question that can be addressed with these data is: what is the history of these populations? There is a long history in population genetics of inferring the relationships among populations as a bifurcating tree, analogous to phylogenetic trees for representing the evolution of species. However, it has long been recognized that, since populations from the same species exchange genes, simple bifurcating trees may be an incorrect representation of population histories. We have developed a method to address this issue, using a model which allows for both population splits and gene flow. In application to humans, we show that we are able to identify a number of both previously known and unknown episodes of gene flow in history, including gene flow into Cambodia of a population only distantly related to modern East Asia. In application to dogs, we show that the boxer and basenji breeds have a considerable component of ancestry from grey wolves subsequent to domestication.}, added-at = {2014-07-01T20:41:29.000+0200}, author = {Pickrell, Joseph K. and Pritchard, Jonathan K.}, biburl = {https://www.bibsonomy.org/bibtex/2faa3b3480191ef47bfcb2c870ead61a4/peter.ralph}, doi = {10.1371/journal.pgen.1002967}, interhash = {d0f0f712c906492616067a84e7506a29}, intrahash = {faa3b3480191ef47bfcb2c870ead61a4}, journal = {PLoS Genet}, keywords = {Wishart_distribution admixture demographic_inference human_genome methods population_genomics}, month = {11}, number = 11, pages = {e1002967}, publisher = {Public Library of Science}, timestamp = {2014-07-01T20:41:29.000+0200}, title = {Inference of Population Splits and Mixtures from Genome-Wide Allele Frequency Data}, url = {http://dx.doi.org/10.1371%2Fjournal.pgen.1002967}, volume = 8, year = 2012 }