%0 Journal Article %1 granoff_induction_1998 %A Granoff, D M %A Gupta, R K %A Belshe, R B %A Anderson, E L %D 1998 %J The Journal of Infectious Diseases %K Adult, Aged, Antibodies, Bacterial Bacterial, Conjugate Humans, Meningococcal Middle Neisseria Polysaccharides, Vaccination, Vaccines, meningitidis, %N 3 %P 870--4 %R 9728562 %T Induction of immunologic refractoriness in adults by meningococcal C polysaccharide vaccination %U http://www.ncbi.nlm.nih.gov/pubmed/9728562 %V 178 %X Thirty-four adults were vaccinated with 1/50 of the usual dose of meningococcal polysaccharide vaccine (1 microg of A, C, Y, and W135 polysaccharides, given intramuscularly). This dose was selected as a probe to assess B cell memory. The probe elicited meningococcal C bactericidal antibody responses in all 18 adults who had been vaccinated 4 years earlier with an investigational meningococcal A and C oligosaccharide-protein conjugate vaccine and in the majority of the 11 subjects vaccinated for the first time. In contrast, the responses of the 5 adults given a full dose of licensed polysaccharide vaccine 4 years earlier were \textless1/10 of those of the other 2 groups. Thus, adults previously given a full dose of meningococcal polysaccharide vaccine show evidence of immunologic refractoriness to group C polysaccharide, whereas refractoriness is not observed after conjugate vaccination. These findings have implications for the use of meningococcal polysaccharide vaccine when the risk of disease is low.

@article{granoff_induction_1998, abstract = {Thirty-four adults were vaccinated with 1/50 of the usual dose of meningococcal polysaccharide vaccine (1 microg of A, C, Y, and W135 polysaccharides, given intramuscularly). This dose was selected as a probe to assess B cell memory. The probe elicited meningococcal C bactericidal antibody responses in all 18 adults who had been vaccinated 4 years earlier with an investigational meningococcal A and C oligosaccharide-protein conjugate vaccine and in the majority of the 11 subjects vaccinated for the first time. In contrast, the responses of the 5 adults given a full dose of licensed polysaccharide vaccine 4 years earlier were {\textless}1/10 of those of the other 2 groups. Thus, adults previously given a full dose of meningococcal polysaccharide vaccine show evidence of immunologic refractoriness to group C polysaccharide, whereas refractoriness is not observed after conjugate vaccination. These findings have implications for the use of meningococcal polysaccharide vaccine when the risk of disease is low.}, added-at = {2011-03-11T10:05:34.000+0100}, author = {Granoff, D M and Gupta, R K and Belshe, R B and Anderson, E L}, biburl = {https://www.bibsonomy.org/bibtex/2d8978ebb8e1009ba37bb05526545cfd7/jelias}, doi = {9728562}, interhash = {d163c4735bac858b0b31083f66cc1f5d}, intrahash = {d8978ebb8e1009ba37bb05526545cfd7}, issn = {0022-1899}, journal = {The Journal of Infectious Diseases}, keywords = {Adult, Aged, Antibodies, Bacterial Bacterial, Conjugate Humans, Meningococcal Middle Neisseria Polysaccharides, Vaccination, Vaccines, meningitidis,}, month = sep, note = {{PMID:} 9728562}, number = 3, pages = {870--4}, timestamp = {2011-03-11T10:06:09.000+0100}, title = {Induction of immunologic refractoriness in adults by meningococcal C polysaccharide vaccination}, url = {http://www.ncbi.nlm.nih.gov/pubmed/9728562}, volume = 178, year = 1998 }