%0 Journal Article %1 Liew2013 %A Liew, Gerald %A Mitchell, Paul %A Wong, Tien Yin %A Rochtchina, Elena %A Wang, Jie Jin %D 2013 %J JAMA internal medicine %K 80andover Aged Aspirin Aspirin:administration&dosage Aspirin:adverseeffects Australia CardiovascularDiseases CardiovascularDiseases:drugtherapy CardiovascularDiseases:prevention&control CohortStudies Female Humans Incidence LogisticModels MacularDegeneration MacularDegeneration:classification MacularDegeneration:epidemiology MacularDegeneration:etiology Male MiddleAged ProspectiveStudies RiskFactors Smoking %N 4 %P 258-64 %R 10.1001/jamainternmed.2013.1583 %T The association of aspirin use with age-related macular degeneration. %U http://www.ncbi.nlm.nih.gov/pubmed/23337937 %V 173 %X OBJECTIVE: To determine whether regular aspirin use is associated with a higher risk for developing age-related macular degeneration (AMD) by using analyzed data from a 15-year prospective cohort. METHODS: A prospective analysis was conducted of data from an Australian population-based cohort with 4 examinations during a 15-year period (1992-1994 to 2007-2009). Participants completed a detailed questionnaire at baseline assessing aspirin use, cardiovascular disease status, and AMD risk factors. Age-related macular degeneration was graded side-by-side from retinal photographs taken at each study visit to assess the incidence of neovascular (wet) AMD and geographic atrophy (dry AMD) according to the international AMD classification. RESULTS: Of 2389 baseline participants with follow-up data available, 257 individuals (10.8%) were regular aspirin users and 63 of the 2389 developed neovascular AMD. Persons who were regular aspirin users were more likely to have incident neovascular AMD: the 15-year cumulative incidence was 9.3% in users and 3.7% in nonusers. After adjustment for age, sex, smoking, history of cardiovascular disease, systolic blood pressure, and body mass index, persons who were regular aspirin users had a higher risk of developing neovascular AMD (odds ratio OR, 2.46; 95% CI, 1.25-4.83). The association showed a dose-response effect (multivariate-adjusted P = .01 for trend). Aspirin use was not associated with the incidence of geographic atrophy (multivariate-adjusted OR, 0.99; 95% CI, 0.59-1.65). CONCLUSION: Regular aspirin use is associated with increased risk of incident neovascular AMD, independent of a history of cardiovascular disease and smoking.

@article{Liew2013, abstract = {OBJECTIVE: To determine whether regular aspirin use is associated with a higher risk for developing age-related macular degeneration (AMD) by using analyzed data from a 15-year prospective cohort. METHODS: A prospective analysis was conducted of data from an Australian population-based cohort with 4 examinations during a 15-year period (1992-1994 to 2007-2009). Participants completed a detailed questionnaire at baseline assessing aspirin use, cardiovascular disease status, and AMD risk factors. Age-related macular degeneration was graded side-by-side from retinal photographs taken at each study visit to assess the incidence of neovascular (wet) AMD and geographic atrophy (dry AMD) according to the international AMD classification. RESULTS: Of 2389 baseline participants with follow-up data available, 257 individuals (10.8%) were regular aspirin users and 63 of the 2389 developed neovascular AMD. Persons who were regular aspirin users were more likely to have incident neovascular AMD: the 15-year cumulative incidence was 9.3% in users and 3.7% in nonusers. After adjustment for age, sex, smoking, history of cardiovascular disease, systolic blood pressure, and body mass index, persons who were regular aspirin users had a higher risk of developing neovascular AMD (odds ratio [OR], 2.46; 95% CI, 1.25-4.83). The association showed a dose-response effect (multivariate-adjusted P = .01 for trend). Aspirin use was not associated with the incidence of geographic atrophy (multivariate-adjusted OR, 0.99; 95% CI, 0.59-1.65). CONCLUSION: Regular aspirin use is associated with increased risk of incident neovascular AMD, independent of a history of cardiovascular disease and smoking.}, added-at = {2023-02-03T11:44:35.000+0100}, author = {Liew, Gerald and Mitchell, Paul and Wong, Tien Yin and Rochtchina, Elena and Wang, Jie Jin}, biburl = {https://www.bibsonomy.org/bibtex/2535f9e76c4b514311725ec72b178287a/jepcastel}, city = {United States}, doi = {10.1001/jamainternmed.2013.1583}, interhash = {d2b5c9b1d7089f1aea10dd96e0cf8b20}, intrahash = {535f9e76c4b514311725ec72b178287a}, issn = {2168-6114}, journal = {JAMA internal medicine}, keywords = {80andover Aged Aspirin Aspirin:administration&dosage Aspirin:adverseeffects Australia CardiovascularDiseases CardiovascularDiseases:drugtherapy CardiovascularDiseases:prevention&control CohortStudies Female Humans Incidence LogisticModels MacularDegeneration MacularDegeneration:classification MacularDegeneration:epidemiology MacularDegeneration:etiology Male MiddleAged ProspectiveStudies RiskFactors Smoking}, month = {2}, note = {JID: 101589534; ppublish;<m:linebreak></m:linebreak> <m:linebreak></m:linebreak>Causalitat; Exemple}, number = 4, pages = {258-64}, pmid = {23337937}, timestamp = {2023-02-03T11:44:35.000+0100}, title = {The association of aspirin use with age-related macular degeneration.}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23337937}, volume = 173, year = 2013 }