%0 Journal Article %1 Evrard1997 %A Evrard, P. %A Marret, S. %A Gressens, P. %D 1997 %J Bull Mem Acad R Med Belg %K Animals; Brain; Cell Death; Cerebral Palsy; Child; Excitatory Amino Acids; Fetus; Humans; Hypoxia, Neuroprotective Agents; Neurotoxins %N 3 %P 159--65; discussion 165-7 %T Excitotoxic cascade and neuroprotection in various stages of cerebral development %V 152 %X Prevalence of cerebral palsy enhanced dramatically during the last decades in some western countries. Pathophysiology of perinatal brain lesions has been revisited. Etiology seems multifactorial including perfusion failure/hypoxia, preconceptional factors, thyroid hormone and growth factors deficiencies, maternal infections with production of cytokines. Excitatory amino acids and excitotoxic cascade seem to be a common final pathway leading to neural cell death. Pharmacological tools destined to inhibit the excitotoxic cascade have been recently developed and are promising for neonatal "neuroprotection".

@article{Evrard1997, abstract = {Prevalence of cerebral palsy enhanced dramatically during the last decades in some western countries. Pathophysiology of perinatal brain lesions has been revisited. Etiology seems multifactorial including perfusion failure/hypoxia, preconceptional factors, thyroid hormone and growth factors deficiencies, maternal infections with production of cytokines. Excitatory amino acids and excitotoxic cascade seem to be a common final pathway leading to neural cell death. Pharmacological tools destined to inhibit the excitotoxic cascade have been recently developed and are promising for neonatal "neuroprotection".}, added-at = {2014-07-19T19:25:36.000+0200}, author = {Evrard, P. and Marret, S. and Gressens, P.}, biburl = {https://www.bibsonomy.org/bibtex/2fc2056a26e6d8da9068bcb02c1523078/ar0berts}, groups = {public}, interhash = {d928da834ed04b75c3eaee0a05bed907}, intrahash = {fc2056a26e6d8da9068bcb02c1523078}, journal = {Bull Mem Acad R Med Belg}, keywords = {Animals; Brain; Cell Death; Cerebral Palsy; Child; Excitatory Amino Acids; Fetus; Humans; Hypoxia, Neuroprotective Agents; Neurotoxins}, number = 3, pages = {159--65; discussion 165-7}, pmid = {9491637}, timestamp = {2014-07-19T19:25:36.000+0200}, title = {[Excitotoxic cascade and neuroprotection in various stages of cerebral development]}, username = {ar0berts}, volume = 152, year = 1997 }