%0 Journal Article %1 Burdakov:2005p45397 %A Burdakov, Denis %D 2005 %J Neur Comp %K Action Animals, Cell Channels, Excitatory Ganglia: Inhibition, Invertebrate, Ion Membrane, Models: Nephropidae, Neural Neurological, Neurons, Pathways Postsynaptic Potentials, Synapses, Synaptic Transmission, %N 5 %P 991--995 %T Gain control by concerted changes in I(A) and I(H) conductances %V 17 %X Stability of intrinsic electrical activity and modulation of input-output gain are both important for neuronal information processing. It is therefore of interest to define biologically plausible parameters that allow these two features to coexist. Recent experiments indicate that in some biological neurons, the stability of spontaneous firing can arise from coregulated expression of the electrophysiologically opposing I(A) and I(H) currents. Here, I show that such balanced changes in I(A) and I(H) dramatically alter the slope of the relationship between the firing rate and driving current in a Hodgkin-Huxley-type model neuron. Concerted changes in I(A) and I(H) can thus control neuronal gain while preserving intrinsic activity.

@article{Burdakov:2005p45397, abstract = {Stability of intrinsic electrical activity and modulation of input-output gain are both important for neuronal information processing. It is therefore of interest to define biologically plausible parameters that allow these two features to coexist. Recent experiments indicate that in some biological neurons, the stability of spontaneous firing can arise from coregulated expression of the electrophysiologically opposing I(A) and I(H) currents. Here, I show that such balanced changes in I(A) and I(H) dramatically alter the slope of the relationship between the firing rate and driving current in a Hodgkin-Huxley-type model neuron. Concerted changes in I(A) and I(H) can thus control neuronal gain while preserving intrinsic activity.}, added-at = {2009-11-12T16:21:13.000+0100}, affiliation = {Neurosciences Division, Biological Sciences, University of Manchester, Manchester, UK. denis.burdakov@man.ac.uk}, author = {Burdakov, Denis}, biburl = {https://www.bibsonomy.org/bibtex/2e2ce0c2ecaa2f75bfa4592ce2566a062/fdiehl}, date-added = {2009-09-23 23:12:25 +0200}, date-modified = {2009-11-10 09:46:52 +0100}, description = {bib-komplett}, interhash = {dbe9541fc42b9a29560ceb1bb064ff53}, intrahash = {e2ce0c2ecaa2f75bfa4592ce2566a062}, journal = {Neur Comp}, keywords = {Action Animals, Cell Channels, Excitatory Ganglia: Inhibition, Invertebrate, Ion Membrane, Models: Nephropidae, Neural Neurological, Neurons, Pathways Postsynaptic Potentials, Synapses, Synaptic Transmission,}, language = {eng}, local-url = {file://localhost/Neurobio/Papers/15881793.pdf}, month = May, number = 5, pages = {991--995}, pmid = {15881793}, rating = {0}, timestamp = {2009-11-12T16:21:16.000+0100}, title = {Gain control by concerted changes in I(A) and I(H) conductances}, uri = {papers://7B65697B-E216-4648-8A41-C67830C0DC73/Paper/p45397}, volume = 17, year = 2005 }