Three-dimensional simulation of calcium waves and contraction in cardiomyocytes using the finite element method.
J. ichi Okada, S. Sugiura, S. Nishimura, and T. Hisada.
Am. J. Physiol. Cell Physiol. 288 (3): C510--C522 (March 2005)

To investigate the characteristics and underlying mechanisms of Ca$^2+$ wave propagation, we developed a three-dimensional (3-D) simulator of cardiac myocytes, in which the sarcolemma, myofibril, and Z-line structure with Ca$^2+$ release sites were modeled as separate structures using the finite element method. Similarly to previous studies, we assumed that Ca$^2+$ diffusion from one release site to another and Ca$^2+$-induced Ca$^2+$ release were the basic mechanisms, but use of the finite element method enabled us to simulate not only the wave propagation in 3-D space but also the active shortening of the myocytes. Therefore, in addition to the dependence of the Ca$^2+$ wave propagation velocity on the sarcoplasmic reticulum Ca$^2+$ content and affinity of troponin C for Ca$^2+$, we were able to evaluate the influence of active shortening on the propagation velocity. Furthermore, if the initial Ca$^2+$ release took place in the proximity of the nucleus, spiral Ca$^2+$ waves evolved and spread in a complex manner, suggesting that this phenomenon has the potential for arrhythmogenicity. The present 3-D simulator, with its ability to study the interaction between Ca$^2+$ waves and contraction, will serve as a useful tool for studying the mechanism of this complex phenomenon.

URL: http://dx.doi.org/10.1152/ajpcell.00261.2004
DOI: 10.1152/ajpcell.00261.2004
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@article{Okad_2005_C510,
  abstract = {To investigate the characteristics and underlying mechanisms of {C}a$^{2+}$
	wave propagation, we developed a three-dimensional (3-D) simulator
	of cardiac myocytes, in which the sarcolemma, myofibril, and Z-line
	structure with {C}a$^{2+}$ release sites were modeled as separate
	structures using the finite element method. Similarly to previous
	studies, we assumed that {C}a$^{2+}$ diffusion from one release site
	to another and {C}a$^{2+}$-induced {C}a$^{2+}$ release were the basic
	mechanisms, but use of the finite element method enabled us to simulate
	not only the wave propagation in 3-D space but also the active shortening
	of the myocytes. Therefore, in addition to the dependence of the
	{C}a$^{2+}$ wave propagation velocity on the sarcoplasmic reticulum
	{C}a$^{2+}$ content and affinity of troponin C for {C}a$^{2+}$, we
	were able to evaluate the influence of active shortening on the propagation
	velocity. Furthermore, if the initial {C}a$^{2+}$ release took place
	in the proximity of the nucleus, spiral {C}a$^{2+}$ waves evolved
	and spread in a complex manner, suggesting that this phenomenon has
	the potential for arrhythmogenicity. The present 3-D simulator, with
	its ability to study the interaction between {C}a$^{2+}$ waves and
	contraction, will serve as a useful tool for studying the mechanism
	of this complex phenomenon.},
  added-at = {2009-06-03T11:20:58.000+0200},
  author = {ichi Okada, Jun and Sugiura, Seiryo and Nishimura, Satoshi and Hisada, Toshiaki},
  biburl = {https://www.bibsonomy.org/bibtex/2c5bd90eee54c7c924d785b572123fd1b/hake},
  description = {The whole bibliography file I use.},
  doi = {10.1152/ajpcell.00261.2004},
  file = {Okad_2005_C510.pdf:Okad_2005_C510.pdf:PDF},
  interhash = {de471d9ec16467743826900b12ad4c83},
  intrahash = {c5bd90eee54c7c924d785b572123fd1b},
  journal = {Am. J. Physiol. Cell Physiol.},
  key = 124,
  keywords = {(Genetics), 15496481 3' Abstract, Acid, Agents, Animals, Anti-Bacterial Bacteria, Bacterial, Base Biological, Calcium Calcium, Cardiac, Complementary, Conserved Contraction, DNA, Drug English Escherichia Factors, Genetic, Genome, Genomics, Gov't, Gram-Negative Gram-Positive Human, Humans, Imaging, Initiation Mathematics, Methicillin Mice, Microbial Models, Muscle Myocytes, Non-U.S. Ofloxacin, Promoter Proteins, RNA RNA, Rats, Regions Regions, Regulatory Research Resistance, Ribonucleic Sensitivity Sequence, Sequences, Signaling, Site, Splicing, Staphylococcus Support, Terminator Tests, Three-Dimensional, Time Transcription Transcription, Untran, Untranslated, aureus, coli, slated},
  month = Mar,
  number = 3,
  pages = {C510--C522},
  pii = {00261.2004},
  pmid = {15496481},
  timestamp = {2009-06-03T11:21:24.000+0200},
  title = {Three-dimensional simulation of calcium waves and contraction in
	cardiomyocytes using the finite element method.},
  url = {http://dx.doi.org/10.1152/ajpcell.00261.2004},
  volume = 288,
  year = 2005
}

%0 Journal Article
%1 Okad_2005_C510
%A ichi Okada, Jun
%A Sugiura, Seiryo
%A Nishimura, Satoshi
%A Hisada, Toshiaki
%D 2005
%J Am. J. Physiol. Cell Physiol.
%K (Genetics), 15496481 3' Abstract, Acid, Agents, Animals, Anti-Bacterial Bacteria, Bacterial, Base Biological, Calcium Calcium, Cardiac, Complementary, Conserved Contraction, DNA, Drug English Escherichia Factors, Genetic, Genome, Genomics, Gov't, Gram-Negative Gram-Positive Human, Humans, Imaging, Initiation Mathematics, Methicillin Mice, Microbial Models, Muscle Myocytes, Non-U.S. Ofloxacin, Promoter Proteins, RNA RNA, Rats, Regions Regions, Regulatory Research Resistance, Ribonucleic Sensitivity Sequence, Sequences, Signaling, Site, Splicing, Staphylococcus Support, Terminator Tests, Three-Dimensional, Time Transcription Transcription, Untran, Untranslated, aureus, coli, slated
%N 3
%P C510--C522
%R 10.1152/ajpcell.00261.2004
%T Three-dimensional simulation of calcium waves and contraction in
	cardiomyocytes using the finite element method.
%U http://dx.doi.org/10.1152/ajpcell.00261.2004
%V 288
%X To investigate the characteristics and underlying mechanisms of Ca$^2+$
	wave propagation, we developed a three-dimensional (3-D) simulator
	of cardiac myocytes, in which the sarcolemma, myofibril, and Z-line
	structure with Ca$^2+$ release sites were modeled as separate
	structures using the finite element method. Similarly to previous
	studies, we assumed that Ca$^2+$ diffusion from one release site
	to another and Ca$^2+$-induced Ca$^2+$ release were the basic
	mechanisms, but use of the finite element method enabled us to simulate
	not only the wave propagation in 3-D space but also the active shortening
	of the myocytes. Therefore, in addition to the dependence of the
	Ca$^2+$ wave propagation velocity on the sarcoplasmic reticulum
	Ca$^2+$ content and affinity of troponin C for Ca$^2+$, we
	were able to evaluate the influence of active shortening on the propagation
	velocity. Furthermore, if the initial Ca$^2+$ release took place
	in the proximity of the nucleus, spiral Ca$^2+$ waves evolved
	and spread in a complex manner, suggesting that this phenomenon has
	the potential for arrhythmogenicity. The present 3-D simulator, with
	its ability to study the interaction between Ca$^2+$ waves and
	contraction, will serve as a useful tool for studying the mechanism
	of this complex phenomenon.

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Three-dimensional simulation of calcium waves and contraction in cardiomyocytes using the finite element method.
J. ichi Okada, S. Sugiura, S. Nishimura, and T. Hisada.
Am. J. Physiol. Cell Physiol. 288 (3): C510--C522 (March 2005)

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BibSonomy

Three-dimensional simulation of calcium waves and contraction in cardiomyocytes using the finite element method.J. ichi Okada, S. Sugiura, S. Nishimura, and T. Hisada. Am. J. Physiol. Cell Physiol. 288 (3): C510--C522 (March 2005)

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Cite this publication

Three-dimensional simulation of calcium waves and contraction in cardiomyocytes using the finite element method.
J. ichi Okada, S. Sugiura, S. Nishimura, and T. Hisada.
Am. J. Physiol. Cell Physiol. 288 (3): C510--C522 (March 2005)