Abstract
A study of the secondary structures of the 5'-leader RNA sequences
of avian leukosis/sarcoma viruses was conducted using phylogenetic
sequence alignment, theoretical structures calculated from base-pairing
interactions involving the calculated minimal delta G values, and
RNaseT1 sensitivity. The results suggest that all of the avian retroviral
RNA leaders may be able to adopt similar conformations. Open reading
frames in the leader RNAs may be positioned to facilitate viral activities
such as translation and packaging of the genomic RNA into virus particles.
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