%0 Journal Article %1 aiello2016component %A Aiello, Gregorio %A Momi, Elena De %A Völgyesi, Péter %A Lédeczi, Ákos %A Valdastri, Pietro %D 2016 %J Sensors and Actuators, A: Physical %K Capsule Design Robots,Medical cyber-physical delivery,Embedded environment,Drug micro-systems,Medical robotics systems,Surgical %P 180--188 %R 10.1016/j.sna.2016.04.035 %T Component based design of a drug delivery capsule robot %V 245 %X Since the introduction of Wireless Capsule Endoscopy (WCE) researchers have started exploring the design space of Medical Capsule Robots (MCRs): embedded micro-systems that can operate autonomously within the human body and can diagnose, prevent, monitor, and cure diseases. Although the research in the area of MCRs is an active topic and has grown exponentially, current devices provide only limited functionalities because their design process is expensive and time consuming. To open this research field to a wider community and, at the same time, create better designs through advanced tool support, in our previous works we presented a design environment for the rapid development of MCRs. In this paper, this environment was adopted to design a Drug Delivery Capsule (DDC) based on a coil-magnet-piston mechanism. The force of the coil acting on the magnetic piston and the drug release profile were modeled and assessed on bench-top with a maximum relative error below 5\%. Then, in vivo trials were performed to validate the DDC functionality with a scheduled drug release profile for a 5 h and 24 min procedure. The resulting design environment template is available open source for further development of drug delivery applications as well as to serve as guideline in prototyping novel MCRs addressing other clinical needs.

@article{aiello2016component, abstract = {Since the introduction of Wireless Capsule Endoscopy (WCE) researchers have started exploring the design space of Medical Capsule Robots (MCRs): embedded micro-systems that can operate autonomously within the human body and can diagnose, prevent, monitor, and cure diseases. Although the research in the area of MCRs is an active topic and has grown exponentially, current devices provide only limited functionalities because their design process is expensive and time consuming. To open this research field to a wider community and, at the same time, create better designs through advanced tool support, in our previous works we presented a design environment for the rapid development of MCRs. In this paper, this environment was adopted to design a Drug Delivery Capsule (DDC) based on a coil-magnet-piston mechanism. The force of the coil acting on the magnetic piston and the drug release profile were modeled and assessed on bench-top with a maximum relative error below 5{\%}. Then, in vivo trials were performed to validate the DDC functionality with a scheduled drug release profile for a 5 h and 24 min procedure. The resulting design environment template is available open source for further development of drug delivery applications as well as to serve as guideline in prototyping novel MCRs addressing other clinical needs.}, added-at = {2023-05-10T16:23:27.000+0200}, author = {Aiello, Gregorio and Momi, Elena De and V{\"{o}}lgyesi, P{\'{e}}ter and L{\'{e}}deczi, {\'{A}}kos and Valdastri, Pietro}, biburl = {https://www.bibsonomy.org/bibtex/26041a39916b9a8c38b8a0fa246d547af/sassw}, doi = {10.1016/j.sna.2016.04.035}, interhash = {e49622c9c4838bce404f9d0b8eee01b6}, intrahash = {6041a39916b9a8c38b8a0fa246d547af}, issn = {09244247}, journal = {Sensors and Actuators, A: Physical}, keywords = {Capsule Design Robots,Medical cyber-physical delivery,Embedded environment,Drug micro-systems,Medical robotics systems,Surgical}, pages = {180--188}, timestamp = {2023-05-10T16:23:27.000+0200}, title = {{Component based design of a drug delivery capsule robot}}, volume = 245, year = 2016 }