%0 Journal Article %1 Scha_1997_1135 %A Schaff, J. %A Fink, C. C. %A Slepchenko, B. %A Carson, J. H. %A Loew, L. M. %D 1997 %J Biophys. J. %K 9284281 Animals, Biological, Calcium, Cell Cells, Computer Electrostatics, Gov't, Models, Neurons, P.H.S., Physiology, Research Simulation, Support, U.S. %N 3 %P 1135--1146 %T A general computational framework for modeling cellular structure and function. %V 73 %X The "Virtual Cell" provides a general system for testing cell biological mechanisms and creates a framework for encapsulating the burgeoning knowledge base comprising the distribution and dynamics of intracellular biochemical processes. It approaches the problem by associating biochemical and electrophysiological data describing individual reactions with experimental microscopic image data describing their subcellular localizations. Individual processes are collected within a physical and computational infrastructure that accommodates any molecular mechanism expressible as rate equations or membrane fluxes. An illustration of the method is provided by a dynamic simulation of IP3-mediated Ca$^2+$ release from endoplasmic reticulum in a neuronal cell. The results can be directly compared to experimental observations and provide insight into the role of experimentally inaccessible components of the overall mechanism.

@article{Scha_1997_1135, abstract = {The "Virtual Cell" provides a general system for testing cell biological mechanisms and creates a framework for encapsulating the burgeoning knowledge base comprising the distribution and dynamics of intracellular biochemical processes. It approaches the problem by associating biochemical and electrophysiological data describing individual reactions with experimental microscopic image data describing their subcellular localizations. Individual processes are collected within a physical and computational infrastructure that accommodates any molecular mechanism expressible as rate equations or membrane fluxes. An illustration of the method is provided by a dynamic simulation of IP3-mediated {C}a$^{2+}$ release from endoplasmic reticulum in a neuronal cell. The results can be directly compared to experimental observations and provide insight into the role of experimentally inaccessible components of the overall mechanism.}, added-at = {2009-06-03T11:20:58.000+0200}, author = {Schaff, J. and Fink, C. C. and Slepchenko, B. and Carson, J. H. and Loew, L. M.}, biburl = {https://www.bibsonomy.org/bibtex/27435ee3a55a9de725b45008d10a3ce17/hake}, description = {The whole bibliography file I use.}, file = {Scha_1997_1135.pdf:Scha_1997_1135.pdf:PDF}, interhash = {e7787c4b4bbe2cab8a9fdb5dcbab7236}, intrahash = {7435ee3a55a9de725b45008d10a3ce17}, journal = {Biophys. J.}, keywords = {9284281 Animals, Biological, Calcium, Cell Cells, Computer Electrostatics, Gov't, Models, Neurons, P.H.S., Physiology, Research Simulation, Support, U.S.}, month = Sep, number = 3, pages = {1135--1146}, pmid = {9284281}, timestamp = {2009-06-03T11:21:28.000+0200}, title = {A general computational framework for modeling cellular structure and function.}, volume = 73, year = 1997 }